Sökning: "Endokrinologi"

Visar resultat 21 - 25 av 331 avhandlingar innehållade ordet Endokrinologi.

  1. 21. Search for MODY and Type 2 diabetes genes

    Författare :Markku Lehto; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; mutation; MODY; mitochondrial DNA; MIDD; insulin deficiency; hepatocyte nuclear factor; Gestational diabetes; glucokinase; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : Diabetes is a heterogeneous disease influenced by both environmental and genetic factors. Maturity-onset diabetes of the young (MODY) is considered as a subform of Type 2 diabetes, which is inherited in an autosomal dominant fashion and expressed at childhood or early adult life. LÄS MER

  3. 22. Genetic interaction between Type 1 and Type 2 diabetes

    Författare :Haiyan Li; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; IDDM2.; Insulin gene VNTR; HLA; IDDM1; mixed type 1 2; Mixed type 1 type 2 diabetes families; LADA; GADabs; Autoantibodies against GAD65; Type 1 diabetes; Type 2 diabetes; diabetology; secreting systems; sekretion; diabetologi; Endokrinologi;

    Sammanfattning : There are two major types of diabetes, type 1 and type 2 diabetes. Similarly characterized by hyperglycaemia and long term micro- and macrovascular complications, type 1 and type 2 diabetes have different underlying pathophysiologic processes. In Scandinavia, type 1 diabetes is common; type 2 diabetes accounts for 85% of all cases with diabetes. LÄS MER

  4. 23. Search for Type 2 Diabetes Susceptibility Genes Using Multiple Approaches

    Författare :Cecilia Lindgren; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; single nucleotide polymorphism SNP ; transmission-disequilibrium test TDT ; genetic variation; single strand conformational polymorphism SSCP ; gene expression; insulin; glucose; genome-wide scan; linkage; genetic association; Type 2 diabetes; early onset diabetes EOD ; sekretion; diabetologi; Endokrinologi; diabetology; Endocrinology; secreting systems; signal-to-noise ratio SNR ;

    Sammanfattning : Type 2 diabetes mellitus is a multifactorial disorder characterized by chronic hyperglycemia resulting from pancreatic dysfunction and insulin resistance. It is a common disorder with a complex pattern of inheritance, likely to reflect the influence of multiple genetic and environmental factors on the diabetes risk. LÄS MER

  5. 24. Hormonal regulation of phosphodiesterase 3B in adipocytes

    Författare :Rebecka Lindh; Signaltransduktionsforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; secreting systems; diabetology; Endokrinologi; Endocrinology; caveolae localization ; phosphorylation interactions ; PDE3B adipocyte adipose tissue diabetes cAMP insulin ; lipolysis caveolin-1 ; sekretion; diabetologi;

    Sammanfattning : Insulin induced activation of the cAMP degrading enzyme phosphodiesterase (PDE) 3B in adipocytes is important for insulin mediated inhibition of lipolysis. The aim of this thesis was to contribute with knowledge on the acute activation of PDE3B in response to insulin and catecholamines in adipocytes. LÄS MER

  7. 25. The Diabetes Incidence Study in Sweden (DISS): Ascertainment, risk factors, and problems with classification

    Författare :Bengt Littorin; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 1; stress; register; life events; incidence; ICA; family characteristics; GADA; epidemiology; diabetes mellitus; classification; Ascertainment; BMI; type 2; unclassifiable; year of diagnosis.; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : The Diabetes Incidence Study in Sweden (DISS) registers diabetes in young adults aged 15-34 years in Sweden. This thesis aims to validate the ascertainment, methods in the classification of diabetes, and putative etiological factors such as family background, psychological stress, and BMI, that may affect the incidence of diabetes in young adults, in the DISS registry. LÄS MER