Sökning: "Endogenous treatment"

Visar resultat 1 - 5 av 432 avhandlingar innehållade orden Endogenous treatment.

  1. 1. Angiostatic treatment of neuroblastoma

    Författare :Erik Wassberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Angiogensis; Angiostatic treatment; Apoptosis; Chromogranin A; Differentiation; Neuroblastoma; 2-Methoxyestradiol; 2-Propynylestradiol; TNP-470; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Neuroblastoma is a malignant solid tumor of childhood with a poor prognosis. The growth of solid tumors has been shown to be dependent on new blood vessel formation, i.e. angiogenesis. LÄS MER

  3. 2. Essays on the Evaluation of Public Policies

    Författare :Michihito Ando; Matz Dahlberg; Che-Yuan Liang; David Neumark; Uppsala universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Local income growth; Local employment; Nuclear power facilities; Synthetic control method; Quantitative case study; Regression kink design; Endogenous treatment; Intergovernmental grants; Flypaper effect; Treatment effect heterogeneity; Instrumental variable; Oral health; Dentures; Price elasticity; Regression discontinuity design; Cost sharing; Randomization test; Economics; Nationalekonomi;

    Sammanfattning : This thesis consists of four self-contained papers.Essay 1: This paper uses the synthetic control (SC) method to examine how the establishment of Nuclear Power Facilities (NPFs) in Japan in the 1970s and 1980s has affected local per capita income levels in the municipalities in which they were located (NPF municipalities). LÄS MER

  4. 3. Cerebrospinal fluid peptidomics: discovery of endogenous peptides as biomarkers of Alzheimer's disease

    Författare :Karl Hansson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Biomarkers; Mass spectrometry; Cerebrospinal fluid; Liquid Chromatography; Endogenous peptides;

    Sammanfattning : Neurodegenerative diseases (NDs), the most prominent example of which is Alzheimer’s disease (AD), has turned out to be among the greatest challenges for modern medicine. Common characteristics of NDs involve the aggregation of proteins, progressive loss of neuronal cells in specific regions of the central nervous system (CNS) and as a result – cognitive and/or functional decline. LÄS MER

  5. 4. Endogenous and treatment-induced neuroplasticity in mouse models of Parkinson's disease

    Författare :Francesco Bez; Basala gangliernas patofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Parkinson´s disease (PD) is an age-related neurodegenerative disorder characterized by a loss of nigral dopamine (DA) neurons that project their axons to the striatum. Striatal DA depletion causes the typical motor symptoms of PD. LÄS MER

  7. 5. Towards Pharmacological Treatment of Cystic Fibrosis

    Författare :Charlotte Andersson; Aleksander Edelman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; cystic fibrosis; airway epithelium; genotype; CFTR; chloride transport; genistein; phenotype; phenylbutyrate; S-nitrosoglutathione; Cellbiologi; Cell biology; Cellbiologi; entomologi; Entomology;

    Sammanfattning : S-nitrosogluthatione is an endogenous substance, present at decreased levels in the lungs of CF patients and was recently found to induce mature CFTR in airway epithelial CF cell lines. We show that S-nitrosoglutathione in physiological concentrations increases the presence of ΔF508 CFTR in the cell membrane and induces cAMP dependent chloride transport in cystic fibrosis airway epithelial cells. LÄS MER