Sökning: "Endocrine tumour"
Visar resultat 1 - 5 av 36 avhandlingar innehållade orden Endocrine tumour.
1. Pancreatic Endocrine Tumourigenesis : Genes of potential importance
Sammanfattning : Understanding signalling pathways that control pancreatic endocrine tumour (PET) development and proliferation may reveal novel targets for therapeutic intervention. The pathogenesis for sporadic and hereditary PETs, apart from mutations of the MEN1 and VHL tumour suppressor genes, is still elusive. LÄS MER
2. Tumour Biological Factors Characterizing Metastasizing Serotonin-producing Ileocaecal Carcinoids
Sammanfattning : In this study, metastasizing serotonin-producing ileocaecal carcinoid tumours (MSPCs) were examined for biological characteristics that could be used to define clinically relevant subgroups within this patient population. Possible targets for new treatment options were also explored. LÄS MER
3. Life Style, Molecular Pathology, and Breast Cancer Risk
Sammanfattning : The breast cancer diagnosis covers a wide range of tumours with different geno- and phenotypic characteristics. The diversity among studies on life-style factors and their impact on breast cancer risk might be clarified by recognizing breast cancer as a heterogeneous disease. LÄS MER
4. Endocrine tumour development : with special focus on chromosome arms 1p and 11q
Sammanfattning : The overall goal of this thesis has been to characterise the involvement of chromosome arms 1p and 11 q in the development of endocrine tumours. The MEN1 gene was analysed as a candidate tumour suppressor gene by screening for mutations in follicular thyroid tumours, malignant melanomas, pheochromocytomas, and abdominal paragangliomas. LÄS MER
5. Characterization of Endocrine Cells and Tumours in the Stomach
Sammanfattning : Enterochromaffin-like (ECL) and ghrelin cells, in the human gastric mucosa and in gastric endocrine tumours (GETs), were subclassified with respect to immunohistochemical reaction vs. vesicular monoamine transporter 2 (VMAT-2), ghrelin/obestatin, and histidine decarboxylase (HDC). LÄS MER