Sökning: "Endocrine disrupting compounds"

Visar resultat 16 - 20 av 27 avhandlingar innehållade orden Endocrine disrupting compounds.

  1. 16. Effects of endocrine disruptors on adreno-cortical and Leydig cell steroidogenesis

    Författare :Vichit Supornsilchai; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endocrine disrupting chemicals EDCs ; steroidogenesis; Leydig cells; adrenocortical cells; steroidogenic acute regulatory protein StAR ; steroidogenic enzymes;

    Sammanfattning : A common sequential pathway for steroidogenesis, designed to produce steroid hormones, is expressed in the adrenal cortex, testes and ovaries. In this process, cholesterol is converted to all known steroids by specific enzymes in a tissue-specific manner. LÄS MER

  3. 17. Interactions between cytochrome P450 and estrogenic compounds in fish

    Författare :Linda Hasselberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cytochrome P450; CYP1A; CYP3A; glutathione; alkylphenols; ethynylestradiol; ketoconazole; vitellogenin; Atlantic cod; rainbow trout; fish;

    Sammanfattning : DISSERTATION ABSTRACT Hasselberg, Linda. Interactions between cytochrome P450 and estrogenic compounds in fish. Department of Zoophysiology, Göteborg University, Box 463, SE-405 30 Göteborg, Sweden Contamination by various pollutions is an environmental concern. LÄS MER

  4. 18. Molecular mechanisms of AhR mediated endocrine disruption of estrogen and retinoic acid signalling pathways

    Författare :David Wahlström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Dioxins and similar compounds are toxic substances ubiquitously present in the environment. The most potent dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is considered to be one of the most toxic compounds known to man. LÄS MER

  5. 19. Diverse effects of endocrine-disruptive chemicals on Leydig and adrenocortical cell steroidogenesis in rodents and humans

    Författare :Iuliia Savchuk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : We are living in a man-made world and often exposed to different chemicals known as endocrine disrupting chemicals (EDCs) that negatively influence our hormonal system. These compounds have the potential to interrupt a normal steroidogenesis and result in harmful effects on the reproductive health of humans and among other organisms. LÄS MER

  7. 20. Neuronal and endocrine cells' susceptibility to physiologic and toxic stimuli : a study on the effects of steroid hormones

    Författare :Eva Ahlbom; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The propensity of a cell to die can be influenced by a number of factors, including hormones, which affect the intracellular and extracellular milieu. The aim of this thesis was to investigate the effects of hormones on cell fate in the nervous system and in the pituitary, with special reference to glucocorticoid and gonadal hormones. LÄS MER