Sökning: "Enantiomeric Separation"

Visar resultat 6 - 10 av 17 avhandlingar innehållade orden Enantiomeric Separation.

1. 6. New Techniques for Chiral Separations

   Författare :Jeanette Olsson; Lars Blomberg; Steen Honoré Hansen; Karlstads universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; analytical chemistry; chiral separation; GC; CE; CEC; Analytical chemistry; Analytisk kemi; Kemi; Chemistry;

   Sammanfattning : Gas chromatography (GC) has been utilized for the study of enantiomer resolution of the atropisomers of PCBs, o,p´-DDD and o,p´-DDT. Different substituents and concentrations of cyclodextrin, capillary dimensions and type of stationary phase films have been investigated to achieve the resolution of as many of the atropisomers on one column as possible. LÄS MER

3. 7. Determination of the Environmental Fate of Drug Substances and the Matrix Effects of Complex Samples in SFC/ESI-MS

   Författare :Alfred Haglind; Curt Pettersson; Mikael Hedeland; Torbjörn Arvidsson; Deirdre Cabooter; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SFC-MS; matrix effect; ion cluster; Supercritical fluid chromatography; ESI; chiral separation; transformation products; LC-QToF; wetland microcosms; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

   Sammanfattning : Awareness of the potential problems caused by drug compounds in the environment has increased over the last decade, both among researchers and with the public. This thesis describes the development of analytical methods and their application to wetlands constructed for purification of wastewater from e.g. drug compounds. LÄS MER

4. 8. Analysis of PCBs with special emphasis on comprehensive two-dimensional gas chromatography of atropisomers

   Författare :Mikael Harju; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Environmental chemistry; PCB; Atropisomers; Chiral; GC×GC; Enantiomeric barriers; Seal; polar; shape selective; Cyclodextrin; 2D; ECD; FID; TOF-MS; Comprehensive two-dimensional GC; Miljökemi; Environmental chemistry; Miljökemi; analytisk kemi; Analytical Chemistry;

   Sammanfattning : There are 209 PCB congeners, 136 of which have been found in technical PCB mixtures and hence may be found in the environment as a result of either intentional or unintentional release. The identification and quantification of the congeners are difficult due to analytical bias from coeluting PCBs and other persistent organic pollutants. LÄS MER

5. 9. Molecular Recognition Studies Based on Imprinting Technology

   Författare :Cong Yu; Tillämpad biokemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; imprinting; molecular recognition; polymer; chiral separation; acrylamide; chromatography; functional monomer; cross-linking; hydrogen bonding; hydrophobic interactions; aqueous media; solvent; antibody; mimics; receptor; artificial enzyme; Bioteknik; Biotechnology; Biokemi; Metabolism; Biochemistry;

   Sammanfattning : In this thesis, I have focused on five main research areas: 1). A new type of imprinted polymer has been developed, namely the amide MIP. The amide functional monomers showed better hydrogen bonding capabilities in polar organic solvents and the resulting polymers exhibited good enantiomeric recognition properties in organic media. LÄS MER

7. 10. Studies on the enantioselective disposition of amlodipine : A challenge in bioanalysis

   Författare :Martin Josefsson; Martin Ahnoff; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : To study the disposition of the enantiomers of the calcium channel blocker amlodipine in human plasma, an enantioselective high performance liquid chromatographic (HPLC) assay was developed. Several HPLC techniques such as chiral ion-pair forming, chiral derivatisation and direct separation on chiral columns were evaluated. LÄS MER