Sökning: "Enantiomeric Separation"

Visar resultat 11 - 15 av 17 avhandlingar innehållade orden Enantiomeric Separation.

  1. 11. Micellar electrokinetic chromatography with laser-induced fluorescence detection applied to the analysis of biological samples

    Författare :Gunnar Thorsén; Andrew G Ewing; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical Chemistry; analytisk kemi;

    Sammanfattning : The research presented in this thesis is focused on the potential for using the combination of micellar electrokinetic chromatography with laser-induced fluorescence detection for the determination of compounds in biological samples. The topics that have been addressed are the development of separation electrolytes, the need for sample preparation procedures, the derivatization of the compounds of interest and the detection of these by laser-induced fluorescence. LÄS MER

  3. 12. Enantioseparation of drugs and related compounds using chiral mobile phase additives

    Författare :Ngoc Hang Huynh; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Sammanfattning : Neutral and anionic chiral mobile phase additives have been employed to separate enantiomers of drugs and related compounds using aqueous buffer solution and hydro-organic solvent mixtures as mobile phases.Ester derivatives of tartaric acid, e. g. LÄS MER

  4. 13. Drug purity determination by capillary electrophoresis : Practical and theoretical aspects on peak shape and resolution

    Författare :Olle Stålberg; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Kemi; Chemistry; Kemi; analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Sammanfattning : Capillary electrophoresis was used for separation and determination ofdrugs. Structural analogues, enantiomers and rotamers were separated usingderivatized β-cyclodextrins and γ-cyclodextrins as selectors.In order to improve these separation systems different kinds of chargedamphiphiles were introduced in the background electrolyte (BGE). LÄS MER

  5. 14. Selectivity and sensitivity in supercritical fluid and liquid chromatography, using capillary columns and microelectrochemical detection

    Författare :Susanne R. Wallenborg; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Kemi; Chemistry; Kemi; Analytical Chemistry; analytisk kemi;

    Sammanfattning : The obtainable selectivity of capillary column supercritical fluid chromatography wasstudied by the direct and indirect enantiomeric separation of some medium polarcompounds, i.e., benzodiazepines. LÄS MER

  7. 15. Development and Validation of HPLC Methods for Analytical and Preparative Purposes

    Författare :Johan Lindholm; Torgny Fornstedt; Karin Caldwell; Karl-Gustaf Wahlund; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; High performance liquid chromatography HPLC ; Analytical biotechnology; Sample preparation; Diode-array-detection DAD ; Mass spectrometry MS ; Validation; Preparative chromatography; Competitive isotherm parameters; Perturbation peak PP method; Kemi; Chemistry; Kemi;

    Sammanfattning : This thesis concerns the development and validation of high performance liquid chromatography (HPLC) methods aimed for two industrially important areas: (i) analysis of biotechnological synthesis and (ii) determination of adsorption isotherm parameters. There is today a lack of detailed recommendations for analytical procedures in the field of biotechnological production of drugs. LÄS MER