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Visar resultat 1 - 5 av 12 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Adaptive Responses by Transcriptional Regulators to small molecules in Prokaryotes : Structural studies of two bacterial one-component signal transduction systems DntR and HpNikR

    Författare :Cyril Dian; Peter Brzezinski; Séan McSweeney; Elisabeth Sauer-Eriksson; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transcription regulator; bacterial biosensor; LysR family; Inducer-binding; nickel-sensing; NikR; signal transduction system; Helicobacter pylori; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Prokaryotes are continually exposed to variations in their environment. Survival in unstable milieu requires a wide range of transcriptional regulators (TRs) that respond to specific environmental and cellular signals by modulating gene expression and provide an appropriate physiological response to external stimuli. LÄS MER

  3. 2. Structural and functional studies of the secreted metalloprotease PrtV from Vibrio cholerae

    Författare :Aaron Edwin; Elisabeth Sauer-Eriksson; Helena Berglund; Umeå universitet; []
    Nyckelord :Cholera; Vibrio cholerae; virulence factors; PrtV; X-ray crystallography; NMR;

    Sammanfattning : Cholera, an acute diarrheal diseases caused by the intestinal infection of the pathogenic bacterium Vibrio cholerae, continues to be a global killer in the world today. PrtV, a secreted zinc metalloprotease, is a potent cytotoxic virulence factor of V. cholerae. LÄS MER

  4. 3. A structural genomics pilot project : methods and applications

    Författare :Ulrika Ericsson; Pär Nordlund; Elisabeth Sauer-Eriksson; Stockholms universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Structural biochemistry; Strukturbiokemi;

    Sammanfattning : With the availability of many completely sequenced genomes, scientific research has shifted from genes to the products of the genes, the proteins. Structural genomics groups have been established worldwide, with the objective of determining protein structures on a genome-wide scale. LÄS MER

  5. 4. Transthyretin from a structural perspective

    Författare :Andreas Hörnberg; Elisabeth Sauer-Eriksson; Hugo Monaco; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; X-ray crystallography; amyloidosis; structural comparison; anomalous diffraction; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Conformational changes in human proteins can induce several types of diseases. The nature of the conformational changes is largely unknown, but some lead to amyloid fibril formation. Amyloid fibrils accumulate in the extra-cellular space of tissues resulting in disruption of organ function. LÄS MER

  7. 5. Structural and functional properties of transthyretin

    Författare :Anders Karlsson; A. Elisabeth Sauer-Eriksson; Salam Al-Karadaghi; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Transthyretin; Amyloidosis; X-ray crystallography; Protein structure; Protein; Structural biology; Strukturbiologi;

    Sammanfattning : The hereditary transthyretin (TTR) amyloidoses are rare, and in severe cases, fatal disorders caused by mutations in the TTR gene. The clinical picture is diverse, involving neuropathies and myopathies, and mainly depends on the causative mutation and the sites and rates of amyloid deposition. LÄS MER