Sökning: "Elisabet Nielsen"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden Elisabet Nielsen.

  1. 1. Pharmacometric Models for Antibacterial Agents to Improve Dosing Strategies

    Författare :Elisabet I Nielsen; Lena E Friberg; Otto Cars; Mats O Karlsson; Marie Sandström; Alan Forrest; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; pharmacokinetics; pharmacodynamics; modeling; NONMEM; antibiotics; in vitro; time-kill curve; PK PD indices; gentamicin; aminoglycosides; newborn infants; premature infants; cystatin C; Biopharmacy; Biofarmaci; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : Antibiotics are among the most commonly prescribed drugs. Although the majority of these drugs were developed several decades ago, optimal dosage (dose, dosing interval and treatment duration) have still not been well defined. LÄS MER

  3. 2. Pharmacometric Approaches to Improve Dose Individualization Methods in Hemophilia A

    Författare :João A. Abrantes; Mats Karlsson; Elisabet I. Nielsen; Siv Jönsson; Ron Mathôt; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bayesian forecasting; coagulation factor VIII; dose adaptation; hemophilia haemophilia A; inter-occasion variability; NONMEM; pharmacodynamics; pharmacokinetics; pharmacometrics; therapeutic drug monitoring; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Hemophilia A is a bleeding disorder caused by the lack of functional coagulation factor VIII (FVIII). The overall aim of this thesis was to improve dose individualization of FVIII replacement therapy in hemophilia A using pharmacometric approaches. LÄS MER

  4. 3. Medication reviews by clinical pharmacists in older hospitalised patients : Implementation, performance and effects

    Författare :Thomas G. H. Kempen; Ulrika Gillespie; Håkan Melhus; Elisabet I. Nielsen; Derek Stewart; Stephen Byrne; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medication review; medication reconciliation; multi-professional collaboration; hospital medicine; polypharmacy; inappropriate prescribing; drug-related problems; medication-related hospital admissions; pragmatic clinical trial; cluster analysis; randomised controlled trial; qualitative analysis; process evaluation; implementation science; Geriatrics; Geriatrik; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy; Internal Medicine; Internmedicin; Hälso- och sjukvårdsforskning; Health Care Research;

    Sammanfattning : Background Inappropriate use of medications is a leading cause of avoidable harm in health care. Medication reviews by clinical pharmacists improve medication use, but evidence on hard clinical outcomes in older hospitalised patients is scarce and implementation in practice is challenging. LÄS MER

  5. 4. Pharmacometric Evaluation of Biomarkers to Improve Treatment in Oncology

    Författare :Ida Netterberg; Lena Friberg; Mats Karlsson; Elisabet I. Nielsen; Henrik Lindman; Amit Roy; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; Biomarkers; Oncology; Population PKPD Modeling; NONMEM; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Cancer is a family of many different diseases with substantial heterogeneity also within the same cancer type. In the era of personalized medicine, it is desirable to identify an early response to treatment (i.e., a biomarker) that can predict the long-term outcome with respect to both safety and efficacy. LÄS MER

  7. 5. New Approaches for Levodopa Treatment in Parkinson’s Disease

    Författare :Marina Senek; Dag Nyholm; Elisabet I Nielsen; Maral Mouradian; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; Pharmacokinetics; Pharmacodynamics; Population modeling; Levodopa; Carbidopa; Entacapone; Microtablets; Intestinal infusion;

    Sammanfattning : Parkinson’s disease (PD) is characterized by degeneration of dopaminergic cells, which results in dopamine depletion. Levodopa is the most effective symptomatic treatment, however, disease progression along with the unfavorable pharmacokinetics of levodopa makes the disease increasingly difficult to treat with time. LÄS MER