Sökning: "Elena Razumovskaya"

Hittade 1 avhandling innehållade orden Elena Razumovskaya.

1. 1. Studies on signaling pathways induced by FLT3, an important oncogene in AML

   Författare :Elena Razumovskaya; Institutionen för translationell medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FLT3; AML; RTK; oncogene; ERK5; hematopoiesis;

   Sammanfattning : FLT3, a receptor tyrosine kinase, is expressed in hematopoietic progenitor cells. FLT3-ITD (internal tandem duplication) and D835 mutations are found in approximately 30% and 7% of Acute Myeloid Leukemia (AML) patients respectively, and correlate with a poor prognosis, thus making the mutated receptor a potential therapeutic target. LÄS MER