Sökning: "Edward Wild"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Edward Wild.

  1. 1. Mapping the Huntington's disease process using cerebrospinal fluid analysis

    Författare :Valter Niemelä; Anne-Marie Landtblom; Dag Nyholm; Jimmy Sundblom; Edward Wild; Uppsala universitet; []
    Nyckelord :Neurodegeneration; Huntingtons disease; Neurogenetics; Neuroinflammation; Neurofilament light; tau; Proenkephalin; Neurology; Neurologi;

    Sammanfattning : Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, caused by a CAG-repeat expansion in the HTT-gene. Today there are no disease-modifying therapies (DMTs), but several promising clinical trials are underway, including therapies that reduce mutant huntingtin expression. LÄS MER

  3. 2. Immuno Gene Therapy of Rat Brain Tumors with interferon-gamma transfected glioma cells

    Författare :Edward Visse; Neurokirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; transplantation; serologi; Immunologi; Immunotherapy; Rat brain tumor; Interferon-gamma; isograft rejection; tumor infiltrating lymphocytes; Immunization; Immunology; serology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Immunotherapy is a new promising approach in cancer treatment. In the future, it will hopefully offer an alternative to existing brain tumors treatments, which are unable to cure. We have established an experimental, low immunogenic, brain tumor model in the rat. LÄS MER

  4. 3. Black mustard and the butterfly effect : metabolomics of plant-insect interactions under multiple stress conditions

    Författare :Stefano Papazian; Benedicte Albrectsen; Edward Farmer; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; plant physiology; metabolomics; glucosinolates; multiple stress; ozone; Brassica nigra; Pieris brassicae; Brevicoryne brassicae; biology; biologi; Environmental Science; miljövetenskap; molekylärbiologi; Molecular Biology; Entomology; entomologi;

    Sammanfattning : One main goal of ecological research is to understand nature´s complexity, in order to predict the potential impact of environmental perturbations. In this thesis, I investigate the ecological interactions between some of the most ancient organisms living on our planet: plants and insects. LÄS MER

  5. 4. Global Ocean Futures : Governance of marine fisheries in the Anthropocene

    Författare :Andrew Merrie; Henrik Österblom; Victor Galaz; Per Olsson; Edward Allison; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; fisheries; futures; global governance; marine ecosystems; scenarios; social-ecological system; Sustainability Science; vetenskap om hållbar utveckling;

    Sammanfattning : This PhD thesis provides an analysis of how an adaptive governance approach can be applied to address existing and emerging challenges in global governance with a focus on marine, wild-capture fisheries. All the papers share a coupled social-ecological framing while providing diverse but complementary perspectives. LÄS MER

  7. 5. Cannabinoids as neuroprotective agents : a mechanistic study

    Författare :Olov Nilsson; Christopher Fowler; Edward Högestätt; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cannabinoid; neuroprotection; inflammation; cytokine; neutrophil; Pharmacology; Farmakologi;

    Sammanfattning : Glucose and oxygen supply to the brain is critical for its proper function and when it is restricted as during a stroke, neurons and glial cells quickly become necrotic leading to structural damage as well as functional impairment and even death. To date there are few effective therapies that inhibit the neurodegenerative process and improves the outcome for the affected individual. LÄS MER