Sökning: "Ectopic fat"

Visar resultat 11 - 15 av 18 avhandlingar innehållade orden Ectopic fat.

  1. 11. MST3 and MST4: Critical Regulators of Liver Lipid Partitioning and Hepatocarcinogenesis

    Författare :Mara Caputo; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; hepatocellular carcinoma; STE20-type kinases; MST3; MST4; lipid droplets; antisense oligonucleotide treatment; fibrosis;

    Sammanfattning : Non-alcoholic fatty liver disease (NAFLD) encompasses a disease spectrum ranging from hepatic steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, and finally cirrhosis. With no approved pharmacological treatment, NAFLD is currently the most common etiology of chronic liver disease in Western countries and its prevalence continues to grow. LÄS MER

  3. 12. Diabetogenic effects of glucocorticoids : role of protein phosphatase 5 and GLP-1 receptor activation

    Författare :Liselotte Fransson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Obesity, the metabolic syndrome and type 2 diabetes are inextricably linked together, and all increase with rapid pace globally. Glucocorticoid (GC) excess is associated with diabetogenic effects, including insulin resistance and glucose intolerance, and a role for GCs has also been proposed in the development and pathology of the metabolic syndrome. LÄS MER

  4. 13. FGF23 - a possible Phosphatonin

    Författare :Richard Marsell; Kenneth Jonsson; Caroline Silve; Uppsala universitet; []
    Nyckelord :Surgery; Fibroblast growth factor 23; FGF23; FGF-23; Phosphate homeostasis; Vitamin D; Klotho; Parathyroid hormone; PTH; Kirurgi;

    Sammanfattning : Human physiology is dependent on an accurate phosphate (Pi) homeostasis. Defective Pi regulation causes hyper- or hypophosphatemia, which are associated with ectopic calcification or impaired bone mineralization, and a shortened life span. Current endocrine models of Pi homeostasis are incomplete. LÄS MER

  5. 14. WISP-2 - A Novel Adipokine Related to Obesity and Insulin resistance

    Författare :John Grünberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adipose tissue; BMP4; Canonical WNT pathway; Insulin Resistance; Obesity; PPARγ; Type 2 Diabetes; WISP2;

    Sammanfattning : Type 2 diabetes mellitus (T2D) is increasing worldwide at an epidemic rate and is expected to reach 592 million inflicted individuals by 2035 as compared to 382 million in 2013. Obesity is a major risk factor for insulin resistance, defined as an impaired cellular effect of insulin, and this precedes the development of T2D. LÄS MER

  7. 15. Metabolic alterations and adipose tissue dysfunction in individuals with a family history of type 2 diabetes

    Författare :Josefin Henninger; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Typ 2 diabetes; Fettvävnadsdysfuntion; Förstagradssläktningar;

    Sammanfattning : ABSTRACT Aims The overall aim of this doctoral thesis was to further examine the anthropometric, metabolic and adipose tissue dysfunctions, as well as explore novel metabolites, associated with type 2 diabetes mellitus (T2D), examining individuals both with and without known genetic predisposition to T2D. This thesis is part of the research conducted at Lundberg laboratory for diabetes research, Institute of Medicine, Sahlgrenska Academy, at Gothenburg University. LÄS MER