Sökning: "Early Response Assessment"

Visar resultat 21 - 25 av 121 avhandlingar innehållade orden Early Response Assessment.

  1. 21. Assessment of Drug-Induced Cardiotoxicity during Rat Embryo Development

    Författare :Mats Nilsson; William S. Webster; Nigel A. Brown; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The potassium ion channel (hERG/IKr) is important for normal heart function and drug-induced blockade of the channel in adult humans can lead to irregular heart rhythms (arrhythmia).  The ion channel is also essential for early cardiac function in the embryo and therapeutic drugs which block this channel have been shown to cause birth defects in animal studies. LÄS MER

  3. 22. New insights in the assessment of right ventricular function : an echocardiographic study

    Författare :Avin Calcutteea; Michael Y Henein; Per Lindqvist; Jan Engvall; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; echocardiography; right ventricle; ischaemic heart disease; pulmonary hypertension; aortic stenosis; aortic valve replacement; three dimensional echocardiography; speckle tracking echocardiography; Cardiology; kardiologi;

    Sammanfattning : Background:  The right ventricle (RV) is multi-compartmental in orientation with a complex structural geometry. However, assessment of this part of the heart has remained an elusive clinical challenge. LÄS MER

  4. 23. Early Environment, Adolescent Alcohol Drinking and Neurobiological Responses to Drugs

    Författare :Sara Palm; Ingrid Nylander; Anne-Lie Svensson; Lundblad Martin; Giancarlo Colombo; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adolescence; beta-endorphin; dopamine; dynorphin; endogenous opioids; enkephalin; high-speed chronoamperometry; housing conditions; maternal separation; multivariate concentric square field™ test; open field test; radioimmunoassay; voluntary alcohol intake; Wistar rats; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : Genes and environment interact to determine an individual’s vulnerability or resilience to several psychiatric disorders, including alcohol use disorder (AUD). Alcohol use is often initiated during adolescence and early onset drinking is associated with increased risk for later AUD. LÄS MER

  5. 24. On the Move : Science and Development Behind Learning Sensorimotor Contingencies in the Mobile Paradigm

    Författare :Umay Sen; Gustaf Gredebäck; Pär Nyström; Philippe Rochat; Uppsala universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; sensorimotor contingencies; mobile paradigm; scientific crisis; response differentiation; Psychology; Psykologi;

    Sammanfattning : Exploring the body and environment is essential for development. Detecting and learning contingent relationships between one’s own actions and their consequences instantiates such exploration. Furthermore, it facilitates the development of sense of agency, body awareness, and consciousness. LÄS MER

  7. 25. Cellular Reactions and Behavioral Changes in Focal and Diffuse Traumatic Brain Injury : A Study in the Rat and Mouse

    Författare :Sara Ekmark Lewén; Lars Hillered; Niklas Marklund; Anders Lewén; Mårten Risling; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Traumatic brain injury; Astrocytes; Inflammatory response; Multivariate concentric square field test; Morris water maze; Exploratory behavior; Risk taking; Functional outcome.; Neurosurgery; Neurokirurgi;

    Sammanfattning : Traumatic brain injury (TBI) is a severe condition and a major cause of death and disability. There is no pharmacological treatment available in clinical practice today and knowledge of brain injury mechanisms is of importance for development of neuroprotective drugs. LÄS MER