Sökning: "Early Response Assessment"

Visar resultat 16 - 20 av 121 avhandlingar innehållade orden Early Response Assessment.

1. 16. Reproductive and Metabolic Consequences of the Polycystic Ovarian Syndrome

   Författare :Miriam Hudecova; Inger Sundström Poromaa; Jan Holte; Matts Olovsson; Per Olof Janson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; polycystic ovarian syndrome; long-term follow-up; ovarian reserve; anti-Müllerian hormone; insulin sensitivity; early insuline response; impaired glucose tolerance; diabetes; endothelial function; endothelial-dependent vasodilation; Obstetrics and gynaecology; Obstetrik och gynekologi; Obstetrik och gynekologi; Obstetrics and Gynaecology;

   Sammanfattning : Polycystic ovary syndrome (PCOS) is a complex clinical condition characterized by hyperandrogenism and chronic oligo/anovulation. Infrequent ovulation and metabolic alterations in women with PCOS are associated with subfertility and probably increased miscarriage rates compared with normal fertile women. LÄS MER

3. 17. Pharmacometrics to improve clinical benefit assessment in oncology

   Författare :Emilie Schindler; Lena E Friberg; Mats O Karlsson; Rik de Greef; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed effect models; NONMEM; pharmacokinetics; pharmacodynamics; VEGF; SLD; targeted therapies; IRT; FDG-PET; SUVmax; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : The high attrition rate in oncology drug development calls for new approaches that would increase the understanding of drugs’ efficacy and safety profiles. This thesis focuses on the development of pharmacometric models to characterize and quantify the relationships between drug exposure, circulating and imaging biomarkers, adverse effects, overall survival (OS), and patient-reported outcomes (PROs). LÄS MER

4. 18. Early perturbations in lipid metabolism in insulin resistance

   Författare :Else Hellebö Johanson; Göteborgs universitet; []
   Nyckelord :insulin resistance; nateglinide; peak VO2; postprandial; relatives; triglyceride-rich lipoproteins; visceral fat; VLDL;

   Sammanfattning : Subjects with the Metabolic Syndrome with or without type 2 diabetes are at excess risk for developing cardiovascular disease. The mechanisms are still not completely understood. Resistance to insulin-stimulated glucose uptake is associated with several metabolic and hemostatic risk factors for cardiovascular disease. LÄS MER

5. 19. Diagnosis and evaluation of therapeutic response of bone metastases

   Författare :Ipek Çiray; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Bone metastases; breast neoplasm; MR imaging; CT; diagnosis; therapy evaluation; Onkologi; Oncology; Onkologi; diagnostisk radiologi; Diagnostic Radiology;

   Sammanfattning : The aim of this study was to investigate different aspects of different imaging modalities in the diagnosis of bone metastases and in the assessment of their response to therapy. The role of CT, with and without clinical information, was investigated as compared to CT-guided bone biopsy in the evaluation of suspected bone metastases. LÄS MER

7. 20. The asthmatic airway response – effects on physiology and biomarkers

   Författare :Henning Stenberg; allergologi och palliativ medicin Lungmedicin; []
   Nyckelord :Asthma; Exhaled breath temperature; Exercise; Allergen challenge; Small airways; Airway provocations; Spirometry; Impulse oscillometry; Inert gas washout; Body plethysmography; Club cell protein CC16 ;

   Sammanfattning : Asthma is a common airway inflammatory disease, associated with a variable degree of airway obstruction. It is a heterogeneous condition with large variations in severity and clinical presentation. Moreover, disease activity can vary from time to time. Taken together, these factors make the diagnosis, monitoring and treatment of asthma challenging. LÄS MER