Sökning: "ETV6 RUNX1"
Visar resultat 1 - 5 av 8 avhandlingar innehållade orden ETV6 RUNX1.
1. Genomic characterization of ETV6/RUNX1-positive acute lymphoblastic leukemia
Sammanfattning : The t(12;21) translocation generates the ETV6/RUNX1 fusion gene, present in 25% of childhood acute lymphoblastic leukemia. This fusion gene is important for leukemia development but is not sufficient for leukemia to arise. LÄS MER
2. Stem and progenitor cell involvement in acute lymphoblastic leukemia
Sammanfattning : Leukemic stem cells (LSCs) share the capacity of self renewal and extensive proliferation with normal hematopoietic stem cells (HSCs), and are therefore obvious targets for therapy. As such, they need to be identified and characterized in order to elucidate what drives them, and what separates them from their normal counterparts. LÄS MER
3. Pediatric Leukemia: Mechanisms of Initiation and Suppression
Sammanfattning : .... LÄS MER
4. Studies of congenital genetic aberrations behind childhood leukemia
Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common cancer in childhood, and most frequently (85%) of B-cell precursor type (BCP-ALL). Acquired chromosomal rearrangements or aneuploidies are the recurrent, often prenatal, initiators of BCP-ALL. LÄS MER
5. Prognostic molecular markers of childhood leukemia
Sammanfattning : During the last decades there has been a dramatic increase in survival rates for childhood leukemia, resulting today in an overall survival close to 90 % for children with acute lymphoblastic leukemia (ALL). This accomplishment is largely due to treatment protocols based on careful risk group assessment guiding the type and intensity of the anti-leukemic treatment. LÄS MER