Sökning: "ESI-MS"

Visar resultat 16 - 20 av 83 avhandlingar innehållade ordet ESI-MS.

  1. 16. Determination of the Environmental Fate of Drug Substances and the Matrix Effects of Complex Samples in SFC/ESI-MS

    Författare :Alfred Haglind; Curt Pettersson; Mikael Hedeland; Torbjörn Arvidsson; Deirdre Cabooter; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SFC-MS; matrix effect; ion cluster; Supercritical fluid chromatography; ESI; chiral separation; transformation products; LC-QToF; wetland microcosms; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Sammanfattning : Awareness of the potential problems caused by drug compounds in the environment has increased over the last decade, both among researchers and with the public. This thesis describes the development of analytical methods and their application to wetlands constructed for purification of wastewater from e.g. drug compounds. LÄS MER

  3. 17. Structural diversity of the lipid A and core oligosaccharide moieties of the lipopolysaccharides from nontypeable and serotype f Haemophilus influenzae

    Författare :Håkan H. Yildirim; Elke Schweda; Andrzej Gamian; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Haemophilus influenzae; LPS; biosynthesis; NMR; ESI-MS;

    Sammanfattning : This thesis describes structural studies of the oligosaccharide and lipid A moieties of lipopolysaccharides (LPSs) isolated from disease-causing Haemophilus influenzae strains. The nontypeable strains were clinical isolates from the middle ear of children suffering from otitis media and the serotype f strains had been collected from three adults with respiratory tract infections. LÄS MER

  4. 18. Protein mass spectrometry in the drug discovery process

    Författare :Agneta Tjernberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Mass spectrometry; ESI-MS; MALDI-TOF MS; drug discovery; protein characterization; dissociation constants;

    Sammanfattning : Most targets for drug discovery are proteins. Drug discovery includes target identification and validation, structural biology, lead generation, lead optimisation, pre-clinical development and clinical trials. The overall aim of this thesis is to apply protein mass spectrometry (MS) in the early drug discovery process. LÄS MER

  5. 19. Structural studies towards the understanding of biosynthesis of the lipopolysaccharide of Haemophilus influenzae

    Författare :Anna Risberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Haemophilus influenzae; structural investigation; lipopolysaccharide LPS ; NMR and electrospray ionization mass spectrometry ESI-MS ;

    Sammanfattning : The thesis Structural studies towards the understanding of biosynthesis of the lipopolysaccharide of Haemophilus influenzae involves structural investigation of LPS of four different H. influenzae strains, RM.118-28, RM.118, RM118-26 and RM. LÄS MER

  7. 20. Mass spectrometric studies of cellulose ethers

    Författare :Dane Momcilovic; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Polymerteknik; biopolymers; Polymer technology; Analytisk kemi; Analytical chemistry; enzymatic depolymerisation; reductive amination; electrospray ionisation; cellulose ethers; MALDI; mass spectrometry;

    Sammanfattning : Cellulose based derivatives, such as cellulose ethers, today find many applications in a diverse range of fields. The numerous applications put high demands on the technological performance of the cellulose ethers. LÄS MER