Sökning: "ESAT-6"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet ESAT-6.

  1. 1. Interplay of human macrophages and Mycobacterium tuberculosis phenotypes

    Författare :Johanna Raffetseder; Maria Lerm; Olle Stendahl; Vesa Loitto; Trude Helen Flo; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mycobacterium tuberculosis; tuberculosis; macrophage; innate immunity; host-pathogen interaction; antibiotic tolerance; phagosomal maturation; bacterial phenotype; dormancy; persistence; virulence factor; ESAT-6; ESX-1;

    Sammanfattning : Mycobacterium tuberculosis (Mtb) is the pathogen causing tuberculosis (TB), a disease most often affecting the lung. 1.5 million people die annually due to TB, mainly in low-income countries. LÄS MER

  3. 2. Evaluation of immunological markers for the diagnosis of active and latent tuberculosis

    Författare :Emilie Wahren Borgström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Tuberculosis (TB) is the single deadliest infectious disease in the world and around one fourth of the global population is estimated to be latently infected with Mycobacterium tuberculosis (Mtb). The World Health Organization (WHO) targets reduction of mortality by 95% and incidence rate by 90% by year 2035. LÄS MER

  4. 3. Improving treatment outcomes for patients with pulmonary tuberculosis in Tanzania : host and pathogen factors

    Författare :Tumaini Joseph Nagu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Tuberculosis (TB) causes more than 1.2 million deaths each year globally. Yet, survivors of tuberculosis are left with long term sequelae of chronic inflammatory responses with consequent reduced quality of life. LÄS MER

  5. 4. Innate immune responses to Mycobacterium tuberculosis infection : How extracellular traps and trained immunity can restrict bacterial growth

    Författare :Clara Braian; Maria Lerm; Olle Stendahl; Parasa Venkata Ramanarao; Nordenfelt Pontus; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis, and the cause of 1.5 million deaths in 2018. During a pulmonary TB infection, the bacterium reaches the lungs and is phagocytosed by cells of the innate immune system, primarily macrophages. LÄS MER

  7. 5. Development of MHC class I African alleles and ex vivo detection of M.tuberculosis-reactive CD8+ T-cells

    Författare :Rebecca Axelsson Robertson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The T-cell mediated adaptive immune response is important in controlling infection with Mycobacterium tuberculosis (M.tb). Several types of T-cells participate in the anti-M.tb defense, including CD4+ and CD8+ cells. LÄS MER