Sökning: "ERK1 2 signalling"

Visar resultat 11 - 15 av 19 avhandlingar innehållade orden ERK1 2 signalling.

  1. 11. HER2 and TP53 in human breast cancer : studies of methods and prognostic value

    Författare :Jenny Bergqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Breast cancer; HER2; c-erbB-2; TP53; tamoxifen; endocrine resistance;

    Sammanfattning : Prognostic and predictive factors are needed for tailored therapy strategies, aimed at reducing breast cancer relapse and improving survival. The present arsenal of such factors is insufficient. LÄS MER

  3. 12. Molecular Mechanisms in Vascular Endothelin B Receptor Up-Regulation

    Författare :Erik Uddman; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; reverse; in vitro pharmacology; organ culture; Endothelin receptors; up-regulation;

    Sammanfattning : Cardiovascular diseases are characterized by changes in morphology and function of the blood vessels. Different signalling molecules are involved in these changes. Endothelin-1 (ET-1) is one of the most potent signalling molecules found in man. Its actions are mediated by two receptors, the ETA and the ETB receptors. LÄS MER

  4. 13. Transcriptional networks in neuroblastoma and breast cancer

    Författare :Christina Manetopoulos; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; basic helix-loop-helix; Neuroblastoma; Breast cancer;

    Sammanfattning : Transcription factors of the basic Helix-loop-helix (bHLH) family of proteins are important regulators of cellular processes such as proliferation and differentiation. Many cancer diseases show a block in differentiation, and aberrant regulation of several bHLH factors have been implicated in the development of different malignancies. LÄS MER

  5. 14. Calcium calmodulin-dependent protein kinase signal transduction in cerebral arteries

    Författare :Roya Waldsee; Lund Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CAMK; Ednothelin receptors; Calcium; gene regulation;

    Sammanfattning : Cerebral arteries participate actively in the response that follows an episode of cerebral ischemia in man and rat. It has been shown that the vascular endothelin receptor expression is increased in stroke and organ culture. LÄS MER

  7. 15. Regulation and Function of the Human Leukotriene D4 Receptor CysLT1 in Epithelial Cells and Colon Cancer

    Författare :Christian Kamp-Nielsen; Malmö Experimentell patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; Inflammation; PKC; Calcium; CysLT1R; GPCR; Cytology; oncology; cancerology; Cytologi; onkologi; cancer;

    Sammanfattning : The pro-inflammatory mediators leukotrienes have shown to be important players in the pathogenesis of diseases like asthma and inflammatory bowel disease (IBD). Patients suffering from IBD have been found to have an increased risk of developing colon cancer. LÄS MER