Sökning: "ERK"
Visar resultat 16 - 20 av 160 avhandlingar innehållade ordet ERK.
16. Modeling normal and malignant hematopoiesis in vitro. To screen for extrinsic regulators and differentiation therapy
Sammanfattning : The incredible thing with blood stem cells, also known as hematopoietic stem cells (HSC), is that they can restore normal hematopoiesis in patients that need a new blood system. Since a prerequisite for successful transplantation is immune compatibility, it requires large donor registries to find a suitable match for a recipient. LÄS MER
17. Kampen för erkännande : DDR:s utrikespolitik gentemot Sverige 1949–1972
Sammanfattning : Since the early 1950’s the foreign policy of the German Democratic Republic (GDR) towards Sweden and the other Western European states was dominated by a striving for diplomatic recognition. This thesis examines that striving through an analysis of the East German-Swedish relations from 1949 until 1972. The main focus is on the years 1954-1972. LÄS MER
18. Renal cell death in urinary tract infections : role of E. coli toxins
Sammanfattning : Febrile urinary tract infections (UTI) are common bacterial illnesses in children. Several follow up studies have shown that 10-15 % of infants with pyelonephritis will develop permanent renal damage, i.e., renal scars, which in turn may lead to chronic diseases such as hypertension and renal insufficiency. LÄS MER
19. A Path for Improving Stroke Recovery. Effects of MEK-ERK1/2 Inhibition
Sammanfattning : The present thesis aimed to shed more light on the notion of acute inhibition of extracellular-signal regulated kinase (ERK)1/2 pathway as a treatment to improve stroke recovery. Stroke is a major cause of death and long-term disability worldwide, classified as ischemic or hemorrhagic. LÄS MER
20. Signaling to and from the sodium pump : effects of insulin and cardiotonic steroids
Sammanfattning : Insulin and proinsulin-connecting peptide (C-peptide) stimulate Na+,K+-ATPase activity. The molecular mechanism by which insulin and C-peptide regulate the Na-pump in differentiated primary human skeletal muscle cells (HSMCs) and primary human renal tubular cells (HRTCs) was determined. LÄS MER