Sökning: "ER retention"

Visar resultat 1 - 5 av 21 avhandlingar innehållade orden ER retention.

  1. 1. Retention of transmembrane proteins in the ER

    Författare :Tommy Nilsson; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  3. 2. Unpacking Employer Branding in the Information Technology Industry

    Författare :Amir Dabirian; Terrence E. Brown; John Ford; KTH; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Employer branding; employer branding value propositions; employer attractiveness; human resources management; recruitment; retention; psychological contract; IT industry; IBM Watson; artificial intelligence; Industrial Economics and Management; Industriell ekonomi och organisation;

    Sammanfattning : Attracting and retaining the best talent is a concern, particularly for knowledge-based firms in high-turnover industries, which rely on a limited supply of highly qualified individuals (Ewing, Pitt, De Bussy, & Berthon, 2002). In 2014, 36% of global employers criticized talent shortages, and in a 2015 study, 73% of CEOs reported being concerned about the availability of workers with key skills (Mosley, 2015). LÄS MER

  4. 3. Selective Retention of β-Carbolines and 7,12-Dimethylbenz[a]anthracene in the Brain : Role of Neuromelanin and Cytochrome P450 for Toxicity

    Författare :Anna Östergren; Eva Brittebo; Nils Gunnar Lindquist; Anne-Lie Svensson; Hans Tjälve; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; β-carboline; neuromelanin; norharman; harman; parkinsonism; Parkinson s disease; motoric impairment; behaviour; glia cells; substantia nigra; dopamine melanin; PC12 cells; ER stress; grp78; hsp90; cytochrome P450; CYP1A1; CYP1B1; blood-brain interfaces; 7; 12-dimethylbenz[a]anthracene; polycyclic aromatic hydrocarbon; endothelial cell; smooth muscle cell; bioactivation; Toxikologi; Toxicology; Toxikologi; Toxicology; toxikologi;

    Sammanfattning : The ß-carbolines norharman and harman structurally resemble the synthetic compound 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) that is known for its ability to damage neuromelanin-containing dopaminergic neurons of the substantia nigra and thereby induce parkinsonism. MPTP is, however, not normally present in the environment whereas the ß-carbolines are present in cooked food and tobacco smoke. LÄS MER

  5. 4. Folding and retention of rotavirus glycoproteins in the endoplasmic reticulum

    Författare :Ali Mirazimi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ER; rotavirus; VP7; NSP4; oligosaccharide processing; N-linked glycosylation; protein disulfide isomerase; calnexin; ATP; ER retention;

    Sammanfattning : The endoplasmic reticulum (ER) is a membrane bound organelle composed of a network of cisternae stretching throughout the cytoplasm. Functionally, the ER performs many essential processes, such as glycosylation, and biosynthesis of lipids; it provides a redox potential condition for forming S-S linkages, and a quality control system, and functions as an intracellular calcium store. LÄS MER

  7. 5. Sorting and processing of neutrophil granule proteins

    Författare :Elinor Bülow; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; secretion; Haematology; extracellular fluids; Hematologi; extracellulära vätskor; cell-specific retention; chimeric; lysosome-related organelles; secretory pathway; propeptide of MPO; azurophil granules;

    Sammanfattning : The neutrophil granulocytes have a critical role in innate immunity in particular through phagocytosis of microorganisms. Their cytoplasmic granule subsets store digestive enzymes and antibiotic proteins that are released during this event. LÄS MER