Sökning: "EPS"
Visar resultat 11 - 15 av 50 avhandlingar innehållade ordet EPS.
11. Pharmacogenetics and Antipsychotic Treatment in Schizophrenia with Special Focus on Adverse Drug Reactions
Sammanfattning : Genetically determined differences in drug metabolism and disposition and drug targets play a pivotal role in the interindividual variability in the clinical outcome of antipsychotic treatment. The aim of this thesis was to study the impact of polymorphisms in genes involved in the pharmacokinetics and pharmacodynamics of antipsychotics, with special focus on their extrapyramidal and metabolic adverse effects. LÄS MER
12. Population Pharmacodynamic Modeling and Methods for D2-receptor Antagonists
Sammanfattning : Early predictions of a potential drug candidate’s time-course of effect and side-effects, based on models describing drug concentrations, drug effects and disease progression, would be valuable to make drug development more efficient. Pharmacodynamic modeling can incorporate and propagate prior knowledge and be used for simulations of different scenarios. LÄS MER
13. Dietary Fibre in Fermented Oats and Barley
Sammanfattning : The physiological characteristics of native and bacterial exopolysaccharides (EPS) in oats and barley-based fermented products were studied in relation to the physico-chemical properties. Article I presents a parallel-randomized double blind clinical trial using a dairy-based product (control), an oat-based product (fermented with V2, which is a mixture (1:1) of Lactobacillus delbrueckii subsp. LÄS MER
14. System Evaluation and Learning in Evolvable Production Systems : Preliminary considerations and research directions
Sammanfattning : Dynamicity and unpredictability related to markets is strongly hardening companies’ mission to follow them and satisfy customer needs mainly due to the lack of adequate engineering mechanisms. These effects are felt more intensively in markets where low volumes and high customisation are needed since this requires constant changes in systems that can range from simple setups to total line re-configuration and re-programing. LÄS MER
15. NMR spectroscopy and MD simulations of carbohydrates
Sammanfattning : Knowledge about the structure, conformation and dynamics of carbohydrates is important in our understanding of the way carbohydrates function in biological systems, for example in intermolecular signaling and recognition. This thesis is a summary of five papers studying these properties in carbohydrate-containing molecules with NMR spectroscopy and molecular dynamics simulations. LÄS MER