Sökning: "EL-4 tumor"

Hittade 4 avhandlingar innehållade orden EL-4 tumor.

  1. 1. Multimodal sentinel lymph node imaging using nanoscale-tailored particles; The importance of particle size

    Författare :Pontus Kjellman; Lund Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; multimodal contrast agent; USPIO; sentinel lymph node; in vivo; EL-4 tumor;

    Sammanfattning : As a cancer grows it will, at a certain stage of disease progression, start spreading in the body. For several types of cancer this spreading will first occur through the lymphatic system and the first place where metastatic cell will be encountered is the first lymph node that drains the area where the tumor is located. LÄS MER

  3. 2. Involvement of T lymphocyte subsets in the rejection of murine tumors by syngeneic or autologous hosts

    Författare :Tao Wen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The aim of this thesis is to study the requirement of CD4+ and CD8+ T Iymphocyte subset, CD28 costimulatory molecule and p56kk for the rejection of syngeneic tumor grafts, and the autochthonous tumors induced by Moloney murine sarcoma virus. It also addresses the role of CD4+ and CD8+ T subsets with regard to the polyomavirus persistence and tumor development. LÄS MER

  4. 3. The role of TPPII in apoptosis control and treatment of malignant disease

    Författare :Hong Xu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :proteasome; tripeptidyl peptidase II; apoptosis; inhibitor of apoptosis LAP ; p53; Phosphoinositid-30H-kinase-related-kinases PIKK ;

    Sammanfattning : Degradation of cytosolic proteins depends largely on the proteasome. This complex contains a catalytic core (20S) and an accessory complex (19S) that recognizes ubiquitinated substrates and translocates these to the catalytic sites in the 20S particle. LÄS MER

  5. 4. Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis

    Författare :Lei Lu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Proteasome; Ubiquitin; Cancer; Neuro-degeneration; Poly-Glutamine; Apoptosis; Tripeptidyl-Peptidase II; Stress; IAP;

    Sammanfattning : The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates are degraded by the 26S proteasome, a large multicatalytic protease complex. LÄS MER