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1. 1. Interphase cytogenetics and cytokine therapy in myelodysplastic syndromes and acute myeloid leukemia

   Författare :Per Bernell; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :myelodysplastic syndromes; acute myeloid leukemia; FISH; clonality; lineageinvolvement; minimal residual disease; EIPO; GM-CSF.;

   Sammanfattning : Myelodysplastic syndromes (MDS) comprise a group of clonal hematopoietic bone marrow cell disorders, characterized by a variable degree of anemia, granulocytopenia and/or thrombocytopenia and with a substantial risk of transformation to acute myeloid leukemia (MDS-AML). In the present thesis a method based on fluorescence in situ hybridization (FISH) was developed which allows cytogenetic studies on morphological identified peripheral blood and bone marrow cells (MGG/FISH). LÄS MER