Sökning: "EGFR"

Visar resultat 11 - 15 av 178 avhandlingar innehållade ordet EGFR.

1. 11. The relationship between reduced renal function and cardiovascular disease

   Författare :Patrik Svensson; Kardiovaskulär forskning - hypertoni; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; eGFR; creatinine; cystatin C; CKD-EPI; CKD; CVD; Genetics; Blood Pressure; Hypertension;

   Sammanfattning : This thesis examines the relationship between measures of renal function and cardiovascular disease (CVD) in patients with hypertension (the NORDIL study) and in the healthy population (Malmö Diet and Cancer Study, MDC) and whether antihypertensive treatment response and the risk of CVD is affected by genetic variation of a regulator of the renal amiloroide sensitive sodium channel (NORDIL). In study 1 we tested creatinine, estimated glomerular filtration rate (eGFR) with Cockroft-Gault (CG) and the MDRD equations and also microalbuminuria (MA) as predictors of CVD, stroke and CVD death. LÄS MER

3. 12. Studies of LRIG1 and the ERBB receptor family in breast and colorectal cancer

   Författare :Ingrid Ljuslinder; Beatrice Malmer; Håkan Hedman; Roger Henriksson; Irina Golovleva; Mef Nilbert; Umeå universitet; []
   Nyckelord :breast cancer; colorectal cancer; LRIG1; EGFR; ERBB2; invasive margin; onkologi; Oncology;

   Sammanfattning : The LRIG1 gene (leucine-rich repeats and immunoglobulin like domains-1) at chromosome 3p14 is a proposed tumour suppressor gene whose gene product negatively regulates various receptor tyrosine kinases. This function has been the basis for classifying LRIG1 as a potential tumour suppressor gene (TSG). LÄS MER

4. 13. Expression and prognostic value of LRIG1 and the EGF-receptor family in renal cell and prostate cancer

   Författare :Marcus Thomasson; Håkan Hedman; Roger Henriksson; Börje Ljungberg; Sten Nilsson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; Renal cell carcinoma; EGFR; ErbB1-4; LRIG1; Oncology; Onkologi; onkologi; Oncology;

   Sammanfattning : The epidermal growth factor receptor (EGFR) family consists of four (EGFR, ErbB2, Erbb3, and ErbB4) receptor tyrosine kinases (RTK) whose signalling is important for physiological and malignant cellular functions such as proliferation, survival, migration, and differentiation. EGFR and ErbB2 in particular are established oncogenes in many solid tumours and are targets for anti-cancer treatment. LÄS MER

5. 14. Experimental studies in brain tumours : with special regard to multidrug resistance and the ErbB-family

   Författare :Ulrika Andersson; Roger Henriksson; Beatrice Malmer; Erik Blomquist; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; glioma; meningioma; endothelium; MDR; Pgp; MRP1; LRP; MGMT; EGFR; ErbB2; ErbB3; ErbB4; Onkologi; Oncology; Onkologi; onkologi; Oncology;

   Sammanfattning : Primary brain tumours, and especially the most common form malignant gliomas, usually display a pronounced resistance to other treatment modalities when surgery fails to cure. Growth factors, such as EGF and its receptor, frequently amplified and overexpressed in malignant gliomas, and factors associated with multidrug resistance have been suggested to at least partially explain the poor outcome. LÄS MER

7. 15. Engineering of Affibody molecules for Radionuclide Molecular Imaging and Intracellular Targeting

   Författare :Camilla Hofström; Torbjörn Gräslund; Serge Muyldermans; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody molecules; affinity proteins; radionuclide molecular imaging; intracellular targeting; EGFR; HER2; IGF-1R; SRA - Molecular Bioscience; SRA - Molekylär biovetenskap;

   Sammanfattning : Affibody molecules are small (7 kDa) affinity proteins of non-immunoglobulin origin that have been generated to specifically interact with a large number of clinically important molecular targets.In this thesis, Affibody molecules have been employed as tracers for radionuclide molecular imaging of HER2- and IGF-1R-expressing tumors, paper I-IV, and for surface knock-down of EGFR, paper V. LÄS MER