Sökning: "EC cell"

Visar resultat 1 - 5 av 82 avhandlingar innehållade orden EC cell.

1. 1. Cellular and molecular roles for CDC42 in angiogenesis

   Författare :Marco Castro; Christer Betsholtz; Bàrbara Laviña; Rui Benedito; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CDC42; angiogenesis; endothelial cell; vascular malformation; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

   Sammanfattning : Angiogenesis is the physiological process by which new blood vessels grow and critically depends on the interplay between the major vascular units: endothelial cells, pericytes and smooth muscle cells. Dysfunction and mispatterning of blood vessels are associated with the progression of many vascular complications, and therefore, understanding the causes of vascular dysmorphia is a central question in vascular biology. LÄS MER

3. 2. Investigating histidine-rich glycoprotein and T cell-specific adaptor as potential biomarkers and therapeutic targets

   Författare :Tor Persson Skare; Lena Claesson-Welsh; Mats Hellström; Elin Sjöberg; Jonas Fuxe; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Histidine-rich glycoprotein; T cell-specifik adaptor; Lymphoma; Glioblastoma; Vascular permeability;

   Sammanfattning : The endothelial cell (EC), the most important cell type in blood vessels, lines the vessel wall and provides vessel integrity. EC function is tightly regulated, and its dysregulation is a key element in many diseases including cardiovascular disease, cancer and several diseases of the eye. LÄS MER

4. 3. TGFβ Signal Transduction in Endothelial Cells

   Författare :Gudrun Valdimarsdóttir; Peter ten Dijke; Carl-Henrik Heldin; Christer Betsholtz; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cellbiologi; Cell biology; Cellbiologi;

   Sammanfattning : Transforming growth factor β (TGFβ) is a multifunctional cytokine that is involved in many biological effects, such as proliferation, migration, differentiation and cell survival. TGFβ regulates cellular responses by binding to a heteromeric complex of type I and type II serine/threonine kinase receptors. LÄS MER

5. 4. Bioinformatics tools for discovery and evaluation of biomarkers : Applications in clinical assessment of cancer

   Författare :Benjamin Ulfenborg; Björn Olsson; Karin Klinga-Levan; Erik Larsson Lekholm; Högskolan i Skövde; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Algorithms; biomarkers; machine learning; classification; cancer; microRNA database; microRNA discovery; partial least squares; Medical sciences; Medicin; Bioinformatik; Bioinformatics; Biomedicin;

   Sammanfattning : Cancer is a disease characterized by abnormal proliferation of cells in the body and ranks as the second leading cause of death worldwide. In order to improve cancer patient care, a major focus of cancer research is to discover biomarkers. LÄS MER

7. 5. Molecular Regulation of Angiogenesis

   Författare :Sofie Mellberg; Lena Claesson-Welsh; Frank Böhmer; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; endothelial morphogenesis; VEGFR-2; protein tyrosine phosphatase; VE-PTP; PTPRB; endocan; ESM-1; angiogenesis; Molecular medicine; Molekylär medicin;

   Sammanfattning : Angiogenesis, de novo formation of blood vessels from the pre-existing vasculature, is crucial in embryo development, and in processes in the adult such as wound healing and ovulation. Angiogenesis is also involved in pathological conditions such as cancer and chronic inflammatory diseases, which are propagated by dysregulated, excess angiogenesis. LÄS MER