Sökning: "EAE MS"

Visar resultat 11 - 15 av 64 avhandlingar innehållade orden EAE MS.

1. 11. Genetic regulation of autoimmune neuroinflammation

   Författare :Kristina Becanovic; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :MS; EAE; QTL; gene regulation; linkage analysis;

   Sammanfattning : Multiple sclerosis (MS) is a complex disease characterized by inflammation and demyelination in the central nervous system (CNS), causing neurological deficits. Although there is an increased familial aggregation rate and evidence for a genetic influence on disease susceptibility, environmental factors are also of importance. LÄS MER

3. 12. Macrophages : as central inflammatory mediators and as targets for therapeutic interventions

   Författare :Åsa Andersson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Macrophages; HMGB1; IL-23; MS; EAE; autoimmunity.;

   Sammanfattning : Macrophages (Mphis) are important cellular players in autoimmune pathogenesis, being the most numerous cells infiltrating sites of inflammation and causing much of the associated tissue damage. Apart from these proinflammatory actions, Mphis also have distinct roles in disease resolution, and effective therapeutic targeting of Mphi-expressed molecules requires understanding of the interplay between different Mphi activators and the kinetics of the induced responses. LÄS MER

4. 13. Studies of cellular pathogenesis in experimental autoimmune encephalomyelitis

   Författare :Judit Wefer; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :EAE; MS; autoimmunity; DNA vaccine; antigen-specific therapies;

   Sammanfattning : In this thesis, I have studied antigen-specific therapeutic interventions of experimental autoimmune encephalomyelitis (EAE) and aimed to understand the respective roles of different cell subsets in initiation and perpetuation of disease. EAE is a commonly used animal model for the human disease Multiple Sclerosis (MS), a demyelinating disease mainly affecting young adults. LÄS MER

5. 14. The complex genetics of experimental autoimmune neuroinflammation

   Författare :Maja Jagodic; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :EAE; MS; QTL; AIL; linkage analysis; gene regulation;

   Sammanfattning : Experimental autoimmune encephalomyelitis (EAE) is an animal model for multiple sclerosis (MS), a chronic inflammatory and demyelinating disease of the central nervous system (CNS). MS is the second most common cause of neurological disability among young adults in the western world. LÄS MER

7. 15. Modulation of immune responses in experimental autoimmune encephalomyelitis

   Författare :Maja Wållberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :MS; EAE; antigen-specific therapy; parasite; modified antigen;

   Sammanfattning : The aim of this thesis work has been to elucidate mechanisms for modulation of the immune response in experimental autoimmune encephalomyelitis (EAE), the animal model for the human disease multiple sclerosis (MS). MS is a degenerative disorder of the central nervous system (CNS) believed to be of autoimmune origin, meaning that components of the immune system attack the tissue in the CNS causing inflammation and destruction. LÄS MER