Sökning: "E. coli ribonucleotide reductase"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden E. coli ribonucleotide reductase.

1. 1. Herpes simplex ribonucleotide reductase

   Författare :Rolf Ingemarson; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Ribonucleotide reductase; herpes simplex virus;

   Sammanfattning : In all bacterial, plant and animal cells, as well as in many viruses, genetic information resides in DNA (deoxyribonucleic acid). Replication of DNA is essential for proliferation, and DNA-containing viruses (such as herpesviruses) must carry out this process within the mammalian cells they infect. LÄS MER

3. 2. Identification and functional characterization of novel thioredoxin systems

   Författare :Anastasios E Damdimopoulos; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Antioxidants; Reactive Oxygen Species; Tbioredoxin; Tbioredoxin Reductase;

   Sammanfattning : Thioredoxins (Trx) are a class of small multifunctional 12-kDa proteins that are characterized by the redox active site Trp-Cys-Gly-Pro-Cys (WCGPC). In the oxidized (inactive) form of Trx (Trx-S2), the two cysteines at the active site form a disulfide bond. LÄS MER

4. 3. Class I Ribonucleotide Reductases : overall activity regulation, oligomerization, and drug targeting

   Författare :Venkateswara Rao Jonna; Anders Hofer; Arne Holmgren; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ribonucleotide reductase; GEMMA; Allosteric regulation; medicinsk biokemi; Medical Biochemistry;

   Sammanfattning : Ribonucleotide reductase (RNR) is a key enzyme in the de novo biosynthesis and homeostatic maintenance of all four DNA building blocks by being able to make deoxyribonucleotides from the corresponding ribonucleotides. It is important for the cell to control the production of a balanced supply of the dNTPs to minimize misincorporations in DNA. LÄS MER

5. 4. Biophysical investigations of ribonucleotide reductase : Activation and inhibition mechanisms

   Författare :Maria Öhrström; Astrid Gräslund; Anders Hofer; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biophysics; Molekylär biofysik; Biophysics; biofysik;

   Sammanfattning : Ribonucleotide reductase (RNR) is the enzyme responsible for de novo synthesis of deoxyribonucleotides, needed for both synthesis and repair of cellular DNA. The RNRs known so far are divided into three distinct classes; I, II and III. The conventional class I enzyme is composed of two separate subunits. LÄS MER

7. 5. Targeting the nucleotide metabolism of the mammalian pathogen Trypanosoma brucei

   Författare :Munender Vodnala; Anders Hofer; Arne Holmgren; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Trypanosoma brucei; adenosine kinase; thymidine kinase; methylthioadenosine phosphorylase; mouser ribonucleotide reductase; E. coli ribonucleotide reductase; RNR; Ara-A; F-Ara-A; dNTP; NTP; doexynucleotide metabolism; nucleosides; nucleoside kinases; allosteric regulation; biologisk kemi; biological chemistry;

   Sammanfattning : Trypanosoma brucei causes African sleeping sickness in humans and Nagana in cattle. There are no vaccines available against the disease and the current treatment is also not satisfactory because of inefficacy and numerous side effects of the used drugs.T. LÄS MER