Sökning: "E Karlsson"
Visar resultat 1 - 5 av 267 avhandlingar innehållade orden E Karlsson.
1. Benefits of Pharmacometric Model-Based Design and Analysis of Clinical Trials
Sammanfattning : Quantitative pharmacokinetic-pharmacodynamic and disease progression models are the core of the science of pharmacometrics which has been identified as one of the strategies that can make drug development more effective. To adequately develop and utilize these models one needs to carefully consider the nature of the data, choice of appropriate estimation methods, model evaluation strategies, and, most importantly, the intended use of the model. LÄS MER
2. Fundamentals of Polyethylene Composites for HVDC Cable Insulation – Interfaces and Charge Carriers
Sammanfattning : Power transmission over long distances by using high voltage direct current (HVDC) cables is important for the transition from fossil energy to using renewable energy sources, e.g. wind, solar and water. LÄS MER
3. Evaluating credal set theory as a belief framework in high-level information fusion for automated decision-making
Sammanfattning : High-level information fusion is a research field in which methods for achieving an overall understanding of the current situation in an environment of interest are studied. The ultimate goal of these methods is to provide effective decision-support for human or automated decision-making. LÄS MER
4. The Importance of Cell-Mediated Immunity for the Development of Type 1 Diabetes
Sammanfattning : Background Type I (insulin-dependent) diabetes mellitus is an autoimmune disease characterised by infiltration of T-lymphocytes in the islets of Langerhans. In particular, activated Th1-like lymphocytes secreting IFN-γ are suggested to contribute to the inflammatory process and the destruction of ß-cells, whereas Th2-like cells producing IL-4 might even be protective. LÄS MER
5. Pharmacokinetic-Pharmacodynamic Modelling of Anticancer Drugs : Haematological Toxicity and Tumour Response in Hollow Fibres
Sammanfattning : Established quantitative relationships between dose, plasma concentrations and response [pharmacokinetic-pharmacodynamic (PKPD) models] have a high potential in improving therapeutic indices of anticancer drug therapy and in increasing drug development efficiency. PKPD modelling is a helpful tool for characterising and understanding schedule dependence. LÄS MER