Sökning: "E Jonsson"

Visar resultat 1 - 5 av 166 avhandlingar innehållade orden E Jonsson.

1. 1. Benefits of Pharmacometric Model-Based Design and Analysis of Clinical Trials

   Författare :Kristin E Karlsson; E Niclas Jonsson; Mats O Karlsson; Anders Grahnén; Michael K Smith; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; model-based analysis; pharmacometrics; modeling; disease progression; NONMEM; SAEM; Importance sampling; repeated time-to-event; RTTCE; RCEpT; NIH stroke scale; Barthel index; internal validation; external validation; study power; study design; PHARMACY; FARMACI; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

   Sammanfattning : Quantitative pharmacokinetic-pharmacodynamic and disease progression models are the core of the science of pharmacometrics which has been identified as one of the strategies that can make drug development more effective. To adequately develop and utilize these models one needs to carefully consider the nature of the data, choice of appropriate estimation methods, model evaluation strategies, and, most importantly, the intended use of the model. LÄS MER

3. 2. Pharmacometric Models for Individualisation of Warfarin in Adults and Children

   Författare :Anna-Karin Hamberg; Mia Wadelius; E Niclas Jonsson; Lena E Friberg; Jeffrey S Barrett; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; warfarin; pharmacokinetics; pharmacodynamics; pharmacometrics; pharmacogenetics; dose individualisation; children; Klinisk farmakologi; Clinical Pharmacology;

   Sammanfattning : Warfarin is one of the most widely used anticoagulants. Therapy is complicated by warfarin’s narrow therapeutic range and pronounced variability in individual dose requirements. Although warfarin therapy is uncommon in children, it is crucial for children with certain congenital or acquired heart diseases. LÄS MER

4. 3. Methodological studies on non-linear mixed effects model building

   Författare :E. Niclas Jonsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

   Sammanfattning : Population analysis of pharmacokinetic/pharmacodynamic (PK/PD) data by the use of non-linear mixed effects modeling offers a number of benefits over traditional methods of analyzing this type of data. These benefits include the possibility to appropriately characterize the typical PK/PD behaviour in the population as well as the associated variability when only a few observations are available for each individual. LÄS MER

5. 4. Holocene climate and atmospheric circulation changes in northern Fennoscandia : Interpretations from lacustrine oxygen isotope records

   Författare :Christina E. Jonsson; Gunhild Rosqvist; Jan Seibert; Philip Barker; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; oxygen isotope; diatom silica; lake sediment; atmospheric circulation; North Atlantic Oscillation; northern Fennoscandia; The Holocene; Little Ice Age; Physical geography; Naturgeografi; Physical Geography; naturgeografi;

   Sammanfattning : This thesis investigates how variations in the oxygen isotopic composition of lake waters in northern Fennoscandia are recorded in lake sediment archives, especially diatoms, and how these variations can be used to infer past changes in climate and atmospheric circulation. Results from analyses of the oxygen isotopic composition of lake water samples (δ18Olakew) collected between 2001 and 2006 show that δ18O of northern Fennoscandian lakes is mainly controlled by the isotopic composition of the precipitation (δ18Op). LÄS MER

7. 5. Cubic Response Theory and the Electromagnetic Properties of Ground and Excited States

   Författare :Dan Jonsson; Aage E. Hansen; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : This thesis is devoted to the study of analytical response theory up to third order and its application to electromagnetic properties of ground and excited states. Computationally tractable expressions for the cubic response function for SCF and MCSCF wave functions have been derived and implemented in a computer code. LÄS MER