Sökning: "Dyslipidemia"

Visar resultat 1 - 5 av 89 avhandlingar innehållade ordet Dyslipidemia.

1. 1. Epidemiological Aspects on Assessing and Treating Dyslipidemia in Type 1 Diabetes : Studies from the Swedish National Diabetes Register

   Författare :Christel Hero; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; dyslipidemia;

   Sammanfattning : Background: Cardiovascular disease (CVD) is a major cause of shortened longevity in individuals with type 1 diabetes. Dyslipidemia is one of the important modifiable risk factors. Aims: To investigate different aspects of dyslipidemia in type 1 diabetes. LÄS MER

3. 2. Zebrafish models for large-scale genetic screens in dyslipidemia and atherosclerosis : Validation and application

   Författare :Manoj Kumar Bandaru; Marcel den Hoed; Anastasia Emmanouilidou; Ingelsson Erik; Shannon Fisher; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; zebrafish; dyslipidemia; atherosclerosis; genetic screens; high-cholesterol diet; APOE; APOB; LDLR; APOC2; PCSK9; LPAR2; GATAD2A; Medicinsk genetik; Medical Genetics;

   Sammanfattning : Hundreds of loci have been robustly associated with circulating lipids, atherosclerosis and coronary artery disease; but for most loci the causal genes and mechanisms remain uncharacterized. The overall aim of my thesis is to develop and validate novel in vivo model systems that are suitable for high-throughput, image-based genetic screens in coronary artery disease and related traits, and use these model systems to systematically characterize positional candidate genes. LÄS MER

4. 3. Genetic Determinants of Dyslipidemia

   Författare :Tibor V Varga; Genetisk och molekylär epidemiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetic epidemiology; Genetic polymorphism; dyslipidaemia; Cholesterol; Triglyceride; Genetic risk; genetic risk score; Single nucleotide polymorphism; Prediction; Gene-environment interactions; Randomized controlled trial; prospective cohort studies; Observational study; GLACIER Study; Diabetes Prevention Program;

   Sammanfattning : Dyslipidemia is a chronic deviation from normal blood lipid levels that can lead to atherosclerosis and other cardiovascular diseases; dyslipidemia and its sequelae are caused by the complex interplay of genetic and environmental factors. Although circulating concentrations of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (LDL-C) have a strong genetic underpinning, not much is known about the genetic factors that affect long-term deteriorations in lipid concentrations. LÄS MER

5. 4. Inflammatory mediators in diabetic retinopathy

   Författare :Carin Gustavsson; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammation; dyslipidemia; diabetic retinopathy; oxidative stress; TNF-alpha; VCAM-1;

   Sammanfattning : Diabetic retinopathy (DR) is the most feared complication of diabetes with an overall prevalence of 21.9-36.8% and may, if untreated, lead to severe visual disability or blindness. LÄS MER

7. 5. Conjugated linoleic acid and the metabolic syndrome : Clinical and metabolic studies with special reference to insulin resistance, oxidative stress and inflammation

   Författare :Ulf Risérus; Keith Frayn; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Metabolic syndrome; dietary fatty acids; conjugated linoleic acid; insulin resistance; oxidative stress; inflammation; cardiovascular disease; dyslipidemia; abdominal obesity; type 2 diabetes; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; Nutrition; näringslära;

   Sammanfattning : The aim of this thesis was to investigate the metabolic effects of conjugated linoleic acid (CLA) in middle-aged men with the metabolic syndrome, a high-risk group for type 2 diabetes. CLA is a group of fatty acid isomers with antiobesity and antidiabetogenic effects in animals, and CLA is therefore used as a supplement in humans. LÄS MER