Sökning: "Dyskinesia"

Visar resultat 11 - 15 av 58 avhandlingar innehållade ordet Dyskinesia.

1. 11. Involvement of non-dopaminergic systems in L-DOPA-induced dyskinsia

   Författare :Daniella Rylander; Basala gangliernas patofysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; Dyskinesia; L-DOPA; 6-OHDA rat model; MPTP monkey model; glutamate; serotonin; DA.; 5-HT;

   Sammanfattning : Parkinson's disease and L-DOPA-induced dyskinesia (LID) does not merely involve the dopamine (DA) system but also include non-dopaminergic systems such as glutamate and serotonin (5-HT). An aberrant glutamate transmission at the corticostriatal synapse, has been linked to LID. LÄS MER

3. 12. Circuit-level analyses of cortico-basal ganglia-thalamic networks. Effects of dopamine dysregulation and experience dependent plasticity

   Författare :Nedjeljka Ivica; Integrativ neurofysiologi; []
   Nyckelord :systems neurophysiology; multi-channel recording; motor control; Parkinson s disease; oscillations; dyskinesia; plasticity;

   Sammanfattning : The cortico-basal ganglia-thalamic (CBT) circuit is thought to be involved in control of voluntary and goal-directed movements and action selection. Dopamine is known to play a crucial role in this circuit and regulating its activity. LÄS MER

4. 13. Dysfunction in the nigrostriatal system : effects of L-DOPA and GDNF

   Författare :Nina Nevalainen; Ingrid Strömberg; Nancy Zahniser; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; L-DOPA; dyskinesia; GDNF; dopamine; glutamate; serotonin; medicinsk utvecklings- och neurobiologi; Developmental Neurosciences;

   Sammanfattning : Parkinson’s disease is a common neurodegenerative disorder caused by nigrostriatal dopamine loss, with motor deficiencies as the primary outcome. To increase the striatal dopamine content, patients are treated with 3,4-dihydroxyphenyl-l-alanine (l-DOPA). LÄS MER

5. 14. The Role of the Cortico-Basal Ganglia-System in Voluntary Movements

   Författare :Martin Tamté; Integrativ neurofysiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurophysiology; Electrophysiology; Pharmacology; Motor Systems; Voluntary movements; Philosophy; In vivo; Corticostriatal; Parkinson s disease; Dyskinesia; Levodopa; Multiple Electrode Arrays;

   Sammanfattning : Bodies with multiple limbs and joints have endless possibilities to move around in their surrounding space. How the nervous system controls this amount of degrees of freedom in motor execution is a question under vigorous debate. LÄS MER

7. 15. Proteomic Characterization of Induced Developmental Neurotoxicity

   Författare :Henrik Alm; Lennart Dencker; R Stuart Cobb; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteomics; Brain Development; Neurotoxicity; 2D-DIGE; Brain Growth Spurt; Polybrominated Diphenyl Ether; Neonatal; Striatum; Hippocampus; Cerebral Cortex; Parkinsonism; Dyskinesia; Toxicology; Toxikologi; Toxicology; Toxikologi;

   Sammanfattning : The developing brain goes through a number of developmental periods during which it displays an increased sensitivity to exogenous disturbances. On such period is the so called “Brain growth spurt” (BGS) which in humans takes place starting from the third trimester of pregnancy and throughout the first few years of life. LÄS MER