Sökning: "Drugs"

Visar resultat 16 - 20 av 2527 avhandlingar innehållade ordet Drugs.

1. 16. Intestinal absorption of drugs : The impact of regional permeability, nanoparticles, and absorption-modifying excipients

   Författare :Carl Roos; Hans Lennernäs; Erik Sjögren; Martin Brandl; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Permeability; intestinal absorption; regional permeability; nanoparticles; nanosuspensions; absorption-modifying excipients; AMEs; Biofarmaci; Biopharmaceutics;

   Sammanfattning : For successful delivery of orally given drug products, the drug compounds must have adequate solubility and permeability in the human gastrointestinal tract. The permeability of a compound is determined by its size and lipophilicity, and is usually evaluated in various pre-clinical models, including rat models. LÄS MER

3. 17. Monitoring of occupational exposure to antineoplastic drugs

   Författare :Maria Hedmer; Avdelningen för arbets- och miljömedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; industrial medicine; Occupational health; plasma; urine; renal clearance; risk evaluation; biological monitoring; air monitoring; wipe sampling; occupational exposure; ifosfamide; antineoplastic drugs; cyclophosphamide; Yrkesmedicin; arbetsmiljömedicin;

   Sammanfattning : Antineoplastic drugs are commonly used in the medical treatment of cancer and some other diseases. Workplaces e.g. hospital pharmacies and wards where antineoplastic drugs are used are contaminated with these drugs and health care workers are therefore at risk of getting occupationally exposed. LÄS MER

4. 18. Common mechanism for teratogenicity of antiepileptic drugs : Drug-induced embryonic arrhythmia and hypoxia-reoxygenation damage

   Författare :Faranak Azarbayjani; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Atiepileptik drugs; embryonic heart; arrhythmia; cleft palate; ROS; antioxidants; Ikr; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Toxicology; toxikologi;

   Sammanfattning : The Antiepilptic drugs (AEDs) phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), tri- and dimethadione (TMD and DMD) are known teratogens having a common malformation pattern in human and animal studies. This thesis was designed chiefly to test a hypothesis correlating the teratogenicity of these AEDs to episodes of pharmacologically induced embryonic arrhythmia and hypoxia-reoxygenation damage. LÄS MER

5. 19. The social ecology of alcohol and drug treatment : Client experiences in context

   Författare :Jessica Storbjörk; Robin Room; Constance Weisner; Stockholms universitet; []
   Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; alcohol; drugs; treatment system; clients; marginalization; social ecology; context; Sweden; Sociology; Sociologi;

   Sammanfattning : The purpose of this thesis is to study how individuals with alcohol and drug problems come to treatment – who is in treatment and who is not? It further studies the goal and role of treatment according to different groups – clients, staff and politicians. How can we understand clients’ experiences in a context?The main data is from the Women and men in Swedish alcohol and drug treatment-study, with a representative sample of clients as well as complementary data on the views of staff and the general population. LÄS MER

7. 20. Preclinical tumor-immune modeling : For the identification of immunomodulatory drugs

   Författare :Tove Selvin; Mårten Fryknäs; Rolf Larsson; Claes Andersson; Malin Jarvius; Brinton Seashore-Ludlow; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immuno-oncology; anti-cancer drugs; preclinical modeling; drug screening; repurposing;

   Sammanfattning : For a long time, the field of cancer research was dominated by a tumor cell-centric view. That, however, changed once it became recognized that medical cancer treatment is largely influenced by the combined effect exerted on both cancer and immune cells. LÄS MER