Sökning: "Drug-Induced: drug therapy"
Visar resultat 1 - 5 av 18 avhandlingar innehållade orden Drug-Induced: drug therapy.
1. Translational studies of drug-induced tumor cell death
Sammanfattning : It is essential to understand the mechanisms of action of anticancer drugs in order to obtain good treatment results. I have in the present thesis studied clinically used anticancer agents as well as other agents that induce tumor cell death. LÄS MER
2. Vaccination against drug-resistant HIV
Sammanfattning : Combinations of antiretroviral drugs against human immunodeficiency virus type 1 (HIV-1) have effectively postponed the progression to acquired immunodeficiency syndrome (AIDS). However, an effective vaccine against HIV-1 would undisputedly be the optimal protective strategy against the virus, especially in resource-poor settings. LÄS MER
3. Models and biomarkers of motor and neuropsychiatric complications in Parkinson’s disease
Sammanfattning : Parkinson's disease (PD) is a neurodegenerative disorder characterised by typicalmotor symptoms that are caused by severe dopamine depletion in the cortico-basalganglia network. Parkinsonian motor symptoms are improved by dopaminergicmedications, the most effective being the dopamine precursor L-DOPA. LÄS MER
4. p53 and cancer-associated fibroblasts : implications for cancer therapy and drug resistance
Sammanfattning : Drug resistance remains as a major problem and a daunting challenge to successful anticancer treatment. Cancer cells are masters of adaptation. Novel drugs that attack cancer in new ways and target key drivers of cancer cell growth are, therefore, urgently needed. LÄS MER
5. Kinetics of HIV-1 drug resistance mutations in vivo
Sammanfattning : Antiretroviral therapy (ARV) exert a selective pressure on HIV-1 and may select viral drug resistant strains which have competitive advantage in the presence of the drug. Knowledge about the appearance and disappearance of these mutations is important when choosing ARV. LÄS MER