Sökning: "Drug Tolerance"

Visar resultat 21 - 25 av 73 avhandlingar innehållade orden Drug Tolerance.

  1. 21. Spread and distribution of drug resistance and compensatory mutations in Plasmodium falciparum

    Författare :Irina Tatiana Jovel Quiñonez Dalmau; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In 2010 there were an estimated 216 million cases of malaria worldwide. In Honduras there were ~9000 cases of which 88% were due to Plasmodium vivax mono-infection. Chloroquine (CQ) resistant Plasmodium falciparum have spread throughout the world curtailing its use. LÄS MER

  3. 22. Nitric oxide generation from nitroglycerin and other no-donors measured in the lung and studies on nitrate tolerance in the cardiovascular system

    Författare :Per Agvald; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Exhaled; nitric oxide; nitroglycerin; nitrite; temperature; tolerance; hypoxia;

    Sammanfattning : Nitroglycerin (GTN) and compounds referred to as nitrovasodilators or NOdonors are frequently used in the treatment of ischemic heart disease. The common mode of action for these drugs is liberation of nitric oxide (NO). Nitric oxide evokes relaxation of smooth muscle through activation of guanylate cyclase with subsequent formation of eGMP. LÄS MER

  4. 23. Development of immunogenicity models in mice for improved risk assessment of biopharmaceuticals

    Författare :Britta Granath; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; anti-drug antibodies; immunogenicity; biopharmaceuticals; immunoglobulin; 3R;

    Sammanfattning : The development of anti-drug-antibodies (ADA) to biopharmaceuticals, e.g. recombinant proteins including monoclonal antibodies (mAb) can lead to adverse events and clinical complications. These include reduced effect of the drug and autoimmune conditions if the administered drug is analogous to endogenous proteins. LÄS MER

  5. 24. Pharmacotherapy for Parkinson's Disease - Observations and Innovations

    Författare :Dag Nyholm; Sten-Magnus Aquilonius; Andrew Lees; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Parkinson s disease; levodopa; pharmacokinetics; infusion; drug delivery systems; electronic patient diary; Neurovetenskap; Neurology; Neurologi; Neurology; Neurologi;

    Sammanfattning : Pharmacotherapy for Parkinson’s disease (PD) is based on levodopa, the most effective dopaminergic drug. The development of motor complications constitutes the major challenge for new or refined therapies. LÄS MER

  7. 25. Search for genetic determinants of Plasmodium falciparum malaria drug resistance in vitro and in vivo

    Författare :Aminatou Kone; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malaria remains the most deadly disease in the world with nearly 627 000 deaths and more than 200 million new clinical cases every year, the large majority occurring in sub Saharan Africa children aged < 5 years. This represents anyway a significant decrease as compared with the situation in the start of the Millennium. LÄS MER