Sökning: "Drosophila melanogaster"

Visar resultat 21 - 25 av 176 avhandlingar innehållade orden Drosophila melanogaster.

  1. 21. Deciphering the Alk signaling pathway in Drosophila

    Författare :Fredrik Hugosson; Ruth H. Palmer; Osamu Shimmi; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drosophila; Alk; RTK; visceral mesoderm; signal transduction; growth factor; transcription factor; molekylärbiologi; Molecular Biology;

    Sammanfattning : In Drosophila melanogaster the visceral mesoderm (VM) develops during embryogenesis in a process where myoblasts become specified to generate two distinct cell types, the founder cells (FCs) and the fusion competent myoblasts (FCMs) that consequently fuses. The cell specification is dependent on cell signaling mediated by the receptor tyrosine kinase (RTK) Anaplastic lymphoma kinase (Alk) and its ligand Jelly belly (Jeb), how this further sets up different identity programs that drive myoblasts to differentiate into FCs and FCMs is still not well understood. LÄS MER

  3. 22. Regulators of chromatin and transcription in Drosophila

    Författare :Filip Crona; Mattias Mannervik; Fernando Azorin; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Transcription; chromatin; co-regulators; CBP; lysine demethylase; KDM4A; Brakeless; Drosophila; utvecklingsbiologi; Developmental Biology;

    Sammanfattning : Development of multicellular organisms is achieved by organized temporal and spatial patterns of gene expression leading to cell differentiation. Chromatin regulators control how the DNA is utilized by altering access of proteins to DNA and thereby function as co-factors in transcription. LÄS MER

  4. 23. Modeling Amyloid Disease in Drosophila melanogaster

    Författare :Ina Berg; Per Hammarström; Stefan Thor; Damian Crowther; Linköpings universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : Amyloid diseases are caused by protein misfolding and aggregation. To date there are 27 known proteins causing amyloid disorders involving brain and peripheral protein deposition. The proteins involved in this mechanism do not share sequence homology, but the amyloid fibrils share biophysical properties and possibly a common pathogenic mechanism. LÄS MER

  5. 24. Cytochrome P-450 in Drosophila melanogaster : activity, genetic variation and regulation

    Författare :Inger Porsch-Hällström; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The cytochrome P-450 enzyme system in the fruit fly, Drosophila melanogaster, was shown to be inducible, to consist of several isozymes and to have the capacity to metabolize a variety of substrates, thus resembling the corresponding mammalian system. These similarities strengthens the value of Drosophila test systems for the detection of indirect carcinogens and mutagens. LÄS MER

  7. 25. Genomic adaptation and gene-dosage regulation of Drosophila melanogaster cells, and long-read software developments

    Författare :Jacob Lewerentz; Per Stenberg; Jan Larsson; Bergman Casey; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Drosophila; cell line; long read; Nanopore; Pacbio; Illumina; cancer; genome evolution; dosage compensation; structural variant; software; bioinformatics;

    Sammanfattning : Cells are the vehicles that allows genetic code to proliferate in the world, taking on various forms – as illustrated by the tree of life. The cell features are determined by the manufacturing of proteins, a process that has its blueprints encoded as genes in the genome. LÄS MER