Sökning: "Down-Regulation"

Visar resultat 1 - 5 av 337 avhandlingar innehållade ordet Down-Regulation.

  1. 1. Effects of Cell Wall Structure on Tensile Properties of Hardwood : Effect of down-regulation of lignin on mechanical performance of transgenic hybrid aspen. Effect of chemical degradation on mechanical performance of archaeological oak from the Vasa ship

    Författare :Ingela Bjurhager; Lars Berglund; Ulrike Wegst; KTH; []
    Nyckelord :tensile strength; transgenic hybrid aspen; lignin down-regulation; the Vasa ship; chemical degradation; longitudinell draghållfasthet; transgen hybridasp; ligninnedreglering; Vasaskeppet; kemisk nedbrytning; TECHNOLOGY; TEKNIKVETENSKAP;

    Sammanfattning : Wood is a complex material and the mechanical properties are influencedby a number of structural parameters. The objective of this study has been toinvestigate the relationship between the structure and the mechanical propertiesof hardwood. Two levels were of special interest, viz. LÄS MER

  2. 2. Bottom-up and top-down regulation of heterogeneous lake food webs

    Författare :Fernando Chaguaceda; Peter Eklöv; Kristin Scharnweber; Lars Tranvik; Blake Matthews; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; food webs; resource coupling; ontogenetic diet shifts; resource specialization; bottom-up; top-down; browning; eutrophication; lake; mesocosms; fatty acids; apparent competition; Biology with specialization in Limnology; Biologi med inriktning mot limnologi;

    Sammanfattning : Food webs are networks of organisms linked by trophic interactions that regulate the responses of ecosystems to environmental change. Such regulation is a result of the effects of resources on the abundance of their consumers (i.e. bottom-up effects) and/or the influence of consumers on the abundance of their resources (i. LÄS MER

  3. 3. Chemically Modified Oligonucleotides: Synthesis, Physicochemical and Biochemical Properties of their Duplexes with DNA and RNA

    Författare :Pushpangadan Indira Pradeepkumar; Jyoti Chattopadhyaya; Jesper Wengel; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Bioorganic chemistry; Antisense oligonucleotides; Dipyridophenazine; Oxetane; RNase H; Gene down-regulation; DNase 1; Charge transport; Bioorganisk kemi; Bioorganic chemistry; Bioorganisk kemi;

    Sammanfattning : This thesis is based on 9 papers dealing with the synthesis, physicochemical and biochemical properties of two types of chemically modified oligonucleotides which have the potential to down-regulate gene expression: (i) The first set is comprised of antisense oligonucleotides (AONs) conjugated with different chromophores of varying size, charge and π-electron density. Conjugation of the chromophores at the 3'- or 5'-end enhanced the target RNA binding affinity and RNase H recruitment capabilities compared to the native counterpart without changing the global helical conformation of their AON/RNA hybrid duplexes. LÄS MER

  4. 4. Molecular dissection of Bruton s tyrosine kinase signaling in hematopoietic cells using RNAi

    Författare :Juhana E Heinonen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : RNA mediated gene silencing, RNA interference (RNAi), has recently been identified in mammalians. This thesis describes the utilization and development of RNAi based tools for signal transduction research. The effects of Bruton s tyrosine kinase (Btk) down-regulation with RNAi have been studied with gene expression profiling in hematopoietic cells. LÄS MER

  5. 5. Alterations in proliferation and differentiation of neural stem cells induced by adverse neurodevelopmental factors

    Författare :Raj Kumar Bose; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Predisposition to diseases can be acquired during early stages of development and resolve into an actual disorder later in life. Early life programming defines the association between challenges during pregnancy that result in altered fetal growth, and developmental and adult disorders. LÄS MER