Sökning: "Down syndrome"
Visar resultat 6 - 10 av 106 avhandlingar innehållade orden Down syndrome.
6. Intellectual Disability and coexisting Autism and ADHD in Down syndrome - a population-based study
Sammanfattning : The thesis investigated associated neurodevelopmental/neuropsychiatric aspects in a population-based cohort of 60 children and adolescents (5–17 years) with Down syndrome (DS).Forty-one subjects were comprehensively assessed by a clinical research team; 17 (41%) and 14 (34%) met DSM criteria for autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), respectively. LÄS MER
7. Induced pluripotent stem cell (iPSC) modelling for the identification of mechanisms behind neurodevelopmental disorders
Sammanfattning : Human induced pluripotent stem cells (iPSCs) have opened new possibilities to recapitulate disease mechanisms and to model disorders in vitro. In the studies presented here, iPSCs were established to model neural differentiation in Down syndrome (DS), caused by trisomy for chromosome 21 (T21); Dravet syndrome (DRS), caused by variants in the SCN1A gene; and an ataxia syndrome, caused by a variant in the NFASC gene. LÄS MER
8. Organ-specific autoantibodies in Addison's disease and autoimmune polyendocrine syndrome type I
Sammanfattning : Assessment of autoantibodies is a valuable tool in the diagnostic procedure of autoimmune diseases. The aim of this study was to investigate the prevalence of different autoantibodies and their associations with disease manifestations in patients with Addison's disease and autoimmune polyendocrine syndrome type I (APS I). LÄS MER
9. Periodontal disease in adolescents with Down syndrome
Sammanfattning : Characterization of virulence factors in P. falciparum malaria is essential in order to identify new therapeutic and prophylactic targets. Rosette formation, the binding of uninfected red blood cells to parasite-infected red blood cells, is a P. falciparum virulence phenotype associated with severe clinical manifestations, e. LÄS MER
10. The sick buidling syndrome
Sammanfattning : This investigation consisted of an intervention study of asingle officebuilding. In the first study, already reported, itwas concluded thatmicrobiological and chemical factors wereunlikely to be responsible forsymptoms of sick buildingsyndrome (SBS) in this building. The focus of theinvestigationtherefore narrowed down to the physical factors. LÄS MER