Sökning: "Dose-Response Relationship"

Visar resultat 6 - 10 av 111 avhandlingar innehållade orden Dose-Response Relationship.

  1. 6. Clinical and experimental studies in corticosteroid contact allergy

    Författare :Marléne Isaksson; Yrkes- och miljödermatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; venereologi; Dermatologi; venereology; Dermatology; inhalation; ROAT; mixes; hydrocortisone-17-butyrate; Corticosteroids; budesonide; tixocortol pivalate; dose-response relationship; clinical relevance; stability; allergic contact dermatitis;

    Sammanfattning : Corticosteroids are anti-inflammatory and anti-proliferative substances that also can induce sensitization, mainly through skin contact. In a sensitized individual, it can be hard to disclose the contact allergy at patch testing because the anti-inflammatory effect may mask the allergic contact reaction. LÄS MER

  2. 7. Microdosimetric description of beam quality and biological effectiveness in radiation therapy

    Författare :Aris Tilikidis; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Dose-response relationship; radiation; Radiotherapy: adverse effects; Radiotherapy dosage; Radiotherapy planning; computer-assisted; Strålningsfysik; Medicin Radioterapi;

    Sammanfattning : .... LÄS MER

  3. 8. Bone and kidney effects from cadmium exposure : dose effect and dose response relationships

    Författare :Tobias Alfvén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Bone; bone mineral density; cadmium; epidemiology; environmental exposure; fractures; heavy metals; human; kidneys; occupationally exposure; osteoporosis; protein HC; tubular proteinuria;

    Sammanfattning : Cadmium is a heavy metal that has been dispersed in the environment during the last century due to human activity. It is well known that high cadmium exposure causes renal damage and in severe cases also osteoporosis and osteomalacia. Osteoporosis is a major cause of morbidity worldwide. LÄS MER

  4. 9. Estimation and optimal designs for multi-response Emax models

    Författare :Bergrún Tinna Magnúsdóttir; Hans Nyquist; Ziad Taib; Nancy Flournoy; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; multi-response Emax models; Clinical Utility Index CUI ; optimal designs; system estimation; dose-response studies.; Statistics; statistik;

    Sammanfattning : This thesis concerns optimal designs and estimation approaches for a class of nonlinear dose response models, namely multi-response Emax models. These models describe the relationship between the dose of a drug and two or more efficacy and/or safety variables. LÄS MER

  5. 10. Transcriptional biomarkers of toxicity – powerful tools or random noise? : An applied perspective from studies on bivalves

    Författare :Gustaf Magnus Oskar Ekelund Ugge; Olof Berglund; Annie Jonsson; Helena Westerdahl; Mikael Ejdebäck; Bruno Nunes; Högskolan i Skövde; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biomarkers; Bivalves; Bivalvia; Ecotoxicology; Environmental toxicology; Environmental risk assessment; RT-qPCR; qPCR; Quantitative PCR; Systematic review; Meta-analysis; Dose-response relationships; Concentration-response relationships; Heavy metals; Metals; General toxicity; Copper; Duck mussel; Anodonta anatina; Freshwater; Gene transcription; Biomarkörer; Musslor; Bivalvia; Ekotoxikologi; Miljötoxikologi; Miljöriskbedömning; RT-qPCR; qPCR; Kvantitativ PCR; Systematic review; Metaanalys; Dos-responssamband; Koncentration-responssamband; Tungmetaller; Metaller; Allmän toxicitet; Koppar; Allmän dammussla; Anodonta anatina; Sötvatten; Gentranskription; Ekologisk modellering; Ecological Modelling Group; Biomarkörer; Musslor; Bivalvia; Ekotoxikologi; Miljötoxikologi; Miljöriskbedömning; RT-qPCR; qPCR; Kvantitativ PCR; Systematic review; Metaanalys; Dos-responssamband; Koncentration-responssamband; Tungmetaller; Metaller; Allmän toxicitet; Koppar; Allmän dammussla; Anodonta anatina; Sötvaten; Gentranskription; Biomarkers; Bivalves; Ecotoxicology; Environmental toxicology; Environmental risk assessment; Quantitative PCR; Meta-analysis; Dose-response relationships; Concentration-response relationships; Heavy metals; Metals; General toxicity; Copper; Duck mussel; Freshwater; Gene transcription;

    Sammanfattning : Aquatic organisms are constantly at risk of being exposed to potentially harmful chemical compounds of natural or anthropogenic origin. Biological life can for instance respond to chemical stressors by changes in gene expression, and thus, certain gene transcripts can potentially function as biomarkers, i.e. LÄS MER