Sökning: "Dose estimation"

Visar resultat 1 - 5 av 78 avhandlingar innehållade orden Dose estimation.

  1. 1. Cellular effects of ionizing radiation : Relevant for understanding cancer risk after medical and environmental radiation exposures

    Författare :Pamela Chiaka Akuwudike; Andrzej Wojcik; Lovisa Lundholm; Kerstin Borgmann; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiation; DNA damage; radiation-induced carcinogenesis; second primary cancer; cisplatin chemoradiotherapy; dose fractionation; low dose; low dose rate; dose and dose rate effectiveness factor DDREF ; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Radiation-induced cancers are stochastic and delayed effects of exposure to ionizing radiation. The dose-response relationship for radiation-induced cancers at both low dose/low dose rates and high doses (doses encountered during radiotherapy) remains unclear. LÄS MER

  3. 2. Estimation and optimal designs for multi-response Emax models

    Författare :Bergrún Tinna Magnúsdóttir; Hans Nyquist; Ziad Taib; Nancy Flournoy; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; multi-response Emax models; Clinical Utility Index CUI ; optimal designs; system estimation; dose-response studies.; Statistics; statistik;

    Sammanfattning : This thesis concerns optimal designs and estimation approaches for a class of nonlinear dose response models, namely multi-response Emax models. These models describe the relationship between the dose of a drug and two or more efficacy and/or safety variables. LÄS MER

  4. 3. Optimal (Adaptive) Design and Estimation Performance in Pharmacometric Modelling

    Författare :Alan Maloney; Ulrika Simonsson; Mats Karlsson; Andy Grieve; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Phase II; dose response; optimal design; adaptive design; exposure response; count data;

    Sammanfattning : The pharmaceutical industry now recognises the importance of the newly defined discipline of pharmacometrics. Pharmacometrics uses mathematical models to describe and then predict the performance of new drugs in clinical development. LÄS MER

  5. 4. Biomarkers of internal exposure/dose : Methods to quantify adducts to protein and DNA by LC/MS studied with benzo[a]pyrene and isocyanates

    Författare :Emelie Westberg; Margareta Törnqvist; Kimmo Peltonen; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biomarker; PAH; serum albumin; adduct; DNA; isocyanate; miljökemi; Environmental Chemistry;

    Sammanfattning : This thesis focuses on methods for quantification by liquid chromatography/mass spectrometry (LC/MS) of specific biomarkers for internal dose of chemicals which induce toxicity through their electrophilic reactivity. In vivo such compounds are short-lived, and could feasibly be measured as their reaction products (adducts) with biomacromolecules. LÄS MER

  7. 5. Optimization of breast tomosynthesis: Computer simulations of image acquisition and glandular dose

    Författare :Hannie Förnvik; Malmö Medicinsk strålningsfysik; []
    Nyckelord :breast tomosynthesis; Monte Carlo simulation; acquisition parameters; software breast phantom; microcalcifications; breast density; glandular dose; glandular distribution;

    Sammanfattning : Breast tomosynthesis (BT) is an X-ray imaging technique recently introduced as an alternative or complement to standard digital mammography (DM) in breast imaging and breast cancer screening. In BT, a set of projection images is acquired over a limited angular range and reconstructed into a volume of slice images. LÄS MER