Sökning: "Domino reactions"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden Domino reactions.

  1. 1. Organocatalytic Domino Reactions

    Författare :Henrik Sundén; Armando Córdova; Pavel Kočovský; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; organocatalytic; domino; iminium-enamine; enamine-iminium; Organic chemistry; Organisk kemi; Organic Chemistry; organisk kemi;

    Sammanfattning : Organocatalyzed reactions involving activation strategies of ketones and aldehydes are important processes in organic chemistry. These activation strategies serve as a versatile platform for the construction of several domino reactions. LÄS MER

  3. 2. New Methods for the Synthesis of Vicinal Stereocenters : Palladium-Catalyzed Domino Reactions and Asymmetric Transfer Hydrogenation

    Författare :Brinton Seashore-Ludlow; Somfai Peter; Kevin Booker-Milburn; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; asymmetric synthesis; domino reactions; palladium-catalyzed reactions; oxindoles; amino alcohols;

    Sammanfattning : In this thesis the synthesis of vicinal stereocenters is investigated in two distinct contexts, namely the construction of 3,3-disubstituted oxindoles and the synthesis of b-hydroxy-a-amino acids. Both scaffolds are prevalent in a range of natural products and biologically relevant compounds and, therefore, methods for their synthesis are of great import. LÄS MER

  4. 3. Palladium(0)-Catalysed Carbonylative Multicomponent Reactions : Synthesis of Heterocycles and the Application of Quinolinyl Pyrimidines as Enzyme Inhibitors

    Författare :Linda Åkerbladh; Mats Larhed; Luke Odell; Anders Karlén; Lise-Lotte Gundersen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Palladium catalysis; Carbonylation; Multicomponent reactions; Domino reactions; Heterocycles; 4-Quinolones; 2-Aminoquinazolinones; Benzoxazinones; N-Acylguanidines; Type II NADH dehydrogenase; NDH-2;

    Sammanfattning : Palladium-catalysed carbonylative multicomponent reactions have proven useful for the synthesis of structurally diverse compounds. Carbon monoxide serves as an atom-efficient, one-carbon building block, which allows for further structural elaboration of the carbonyl compound. LÄS MER

  5. 4. Palladium(II)-Catalyzed Heck Reactions : Domino Reactions, Decarboxylations, Mechanistic Studies & Continuous Flow Applications

    Författare :Ashkan Fardost; Mats Larhed; Patrick Guiry; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; palladium II ; dft; reaction mechanisms; esi-ms; heck; decarboxylation; microwave; continuous flow;

    Sammanfattning : This thesis describes research efforts dedicated to the development of palladium(II)-catalyzed oxidative Heck and Heck/Suzuki domino reactions, and the applications of a new microwave heating technology, purpose-built for continuous flow in organic synthesis.Paper I describes the development of a ligand-modulated approach for attaching aryl groups to a chelating vinyl ether. LÄS MER

  7. 5. Synthesis of Indole Alkaloids and Development of New Methodology

    Författare :Anita Hoang; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; total synthesis; indole alkaloids; Domino reactions; vicinal quaternary stereocenters; quaternary stereocenter; indoline synthesis; communesin alkaloid; perophoramidine; dehaloperophoramidine; akuammiline alkaloids; strictamine; intramolecular Heck reaction; domino carbopalladation carbonylation; indoline alkaloids;

    Sammanfattning : This thesis describes our efforts towards the total synthesis of natural products and the development of a newmethodology to afford a synthetically important scaffold.Chapter 2 outlines our efforts towards the total synthesis of a marine natural product, perophoramidine as wellas our completed synthesis of dehaloperophoramidine. LÄS MER