Sökning: "Domino reactions"
Visar resultat 1 - 5 av 12 avhandlingar innehållade orden Domino reactions.
1. Organocatalytic Domino Reactions
Sammanfattning : Organocatalyzed reactions involving activation strategies of ketones and aldehydes are important processes in organic chemistry. These activation strategies serve as a versatile platform for the construction of several domino reactions. LÄS MER
2. New Methods for the Synthesis of Vicinal Stereocenters : Palladium-Catalyzed Domino Reactions and Asymmetric Transfer Hydrogenation
Sammanfattning : In this thesis the synthesis of vicinal stereocenters is investigated in two distinct contexts, namely the construction of 3,3-disubstituted oxindoles and the synthesis of b-hydroxy-a-amino acids. Both scaffolds are prevalent in a range of natural products and biologically relevant compounds and, therefore, methods for their synthesis are of great import. LÄS MER
3. Palladium(0)-Catalysed Carbonylative Multicomponent Reactions : Synthesis of Heterocycles and the Application of Quinolinyl Pyrimidines as Enzyme Inhibitors
Sammanfattning : Palladium-catalysed carbonylative multicomponent reactions have proven useful for the synthesis of structurally diverse compounds. Carbon monoxide serves as an atom-efficient, one-carbon building block, which allows for further structural elaboration of the carbonyl compound. LÄS MER
4. Palladium(II)-Catalyzed Heck Reactions : Domino Reactions, Decarboxylations, Mechanistic Studies & Continuous Flow Applications
Sammanfattning : This thesis describes research efforts dedicated to the development of palladium(II)-catalyzed oxidative Heck and Heck/Suzuki domino reactions, and the applications of a new microwave heating technology, purpose-built for continuous flow in organic synthesis.Paper I describes the development of a ligand-modulated approach for attaching aryl groups to a chelating vinyl ether. LÄS MER
5. Synthesis of Indole Alkaloids and Development of New Methodology
Sammanfattning : This thesis describes our efforts towards the total synthesis of natural products and the development of a newmethodology to afford a synthetically important scaffold.Chapter 2 outlines our efforts towards the total synthesis of a marine natural product, perophoramidine as wellas our completed synthesis of dehaloperophoramidine. LÄS MER