Sökning: "Domain Evolution"

Visar resultat 1 - 5 av 155 avhandlingar innehållade orden Domain Evolution.

  1. 1. Influenza neuraminidase assembly Evolution of domain cooperativity

    Detta är en avhandling från Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Författare :Diogo da Silveira Vieira da Silva; Robert Daniels; Ron Fouchier; [2016]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Influenza; neuraminidase; assembly; transmembrane domain; evolution; biokemi; Biochemistry;

    Sammanfattning : Influenza A virus (IAV) is one of the most common viruses circulating in the human population and is responsible for seasonal epidemics that affect millions of individuals worldwide. The need to develop new drugs and vaccines against IAVs led scientists to study the main IAV surface antigens hemagglutinin (HA) and neuraminidase (NA). LÄS MER

  2. 2. Probabilistic Modelling of Domain and Gene Evolution

    Detta är en avhandling från Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Författare :Sayyed Auwn Muhammad; Jens Lagergren; Bastien Boussau; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Phylogenetics; Phylogenomics; Evolution; Domain Evolution; Gene tree; Domain tree; Bayesian Inference; Markov Chain Monte Carlo; Homology Inference; Gene families; C2H2 Zinc-Finger; Reelin Protein; Computer Science; Datalogi;

    Sammanfattning : Phylogenetic inference relies heavily on statistical models that have been extended and refined over the past years into complex hierarchical models to capture the intricacies of evolutionary processes. The wealth of information in the form of fully sequenced genomes has led to the development of methods that are used to reconstruct the gene and species evolutionary histories in greater and more accurate detail. LÄS MER

  3. 3. Protein Folding, Binding and Evolution PDZ domains and paralemmins as model systems

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Greta Hultqvist; Per Jemth; Ruth Nussinov; [2013]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein folding; evolution; binding; allostery; Paralemmin; PDZ domain;

    Sammanfattning : Proteins present at the synapse need to be multitasking in order to perform all vital functions in this limited space. In this thesis I have analyzed the function and evolution of such proteins, focusing on the PDZ domain and the paralemmin family. The PDZ domains bind to a wide variety of interaction partners. LÄS MER

  4. 4. Haptoglobin: Biosynthesis and Evolution

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Krzysztof B. Wicher; Erik Fries; John W. M. Creemers; [2006]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; haptoglobin; cleavage; C1r-LP; evolution; vertebrate; endoplasmic; Golgi; complement; Molekylärbiologi; NATURAL SCIENCES Biology Cell and molecular biology Molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Molekylärbiologi;

    Sammanfattning : Haptoglobin (Hp) is a serum protein known for its ability to form a tight complex with hemoglobin (Hb) and thereby inhibiting the oxidative activity of Hb. Mammalian Hp is synthesized as a precursor (proHp) that undergoes proteolytic cleavage by a previously unidentified enzyme in the endoplasmic reticulum (ER). LÄS MER

  5. 5. Simulation of radiation damage in Fe and Fe-Cr

    Detta är en avhandling från Stockholm : KTH

    Författare :Christina Lagerstedt; Jan Wallenius; Cristophe Domain; [2005]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES Physics; NATURVETENSKAP Fysik;

    Sammanfattning : Steel is an important structural material in nuclear reactors used for example in pressure vessels and fast reactor cladding. In reactor environments it has been observed that ferritic steels are more resistant to swelling than the austenitic steels typically used. LÄS MER