Sökning: "Disulfiram"

Hittade 5 avhandlingar innehållade ordet Disulfiram.

  1. 1. Alcohol-sensitizing compounds : studies on the biochemical and pharmacological effects of disulfiram (antabuse), cyanamide and coprine on rats, with special reference to the disulfiram-ethanol reaction

    Författare :Ewa Hellström; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : .... LÄS MER

  3. 2. Alcohol-sensitizing compounds : studies on the mode of action of disulfiram, cyanamide and 1-aminocyclopropanol on the acetaldehyde metabolism in rats

    Författare :Hans Marchner; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : .... LÄS MER

  4. 3. New Methods to Screen for Cancer Drugs and to Evaluate their Mechanism of Action

    Författare :Linda Rickardson; Rolf Larsson; Peter Nygren; Henrik Lövborg; Kjell Grankvist; Uppsala universitet; []
    Nyckelord :Pharmacology; Cancer drugs; Screening; Gene expression; Farmakologi;

    Sammanfattning : Cancer is a common disease and due to problems with resistance against cancer drugs and the limited benefit from chemotherapy in many diagnoses, there is a need to develop new cancer drugs. In this thesis new methods to screen for cancer drugs and to evaluate their mechanism of action are discussed. LÄS MER

  5. 4. Computational and chemical approaches to drug repurposing

    Författare :Xuexin Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Drug repurposing, which entails discovering novel therapeutic applications for already existing drugs, provides numerous benefits compared to conventional drug discovery methods. This strategy can be pursued through two primary approaches: computational and chemical. LÄS MER

  7. 5. Thiol redox state in apoptosis : physiological and toxicant modulation

    Författare :Stefan Nobel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Apoptosis is a physiological type of cell death used to regulate the number of cells during development and in adult organs. However, apoptosis can also be inappropriately activated or inhibited under pathological conditions. One of the critical mechanisms of apoptosis is the activity of cysteine proteases belonging to the caspase family. LÄS MER