Sökning: "Dissolution Methods"
Visar resultat 1 - 5 av 92 avhandlingar innehållade orden Dissolution Methods.
1. Evaluation of a Miniaturized Rotating Disk Apparatus for In Vitro Dissolution Rate Measurements in Aqueous Media : Correlation of In Vitro Dissolution Rate with Apparent Solubility
Sammanfattning : The general aim of this thesis was to evaluate a newly designed and constructed miniaturized rotating disk apparatus for in vitro dissolution rate measurements of different drug substances from all of the classes in the Biopharmaceutical Classification System (BCS). The new equipment is based on a low volume flow-through cell of Plexiglas, a gold plated magnetic bar and a special designed press. LÄS MER
2. Novel and refined small-scale approaches to determine the intrinsic dissolution rate of drugs
Sammanfattning : Many drugs are administered as crystalline particles compressed into tablets and taken orally. When the tablet reaches the gastrointestinal tract, it disintegrates and the drug particles dissolve in the gastrointestinal fluid. The dissolved molecules are absorbed across the intestinal membranes into the bloodstream to reach their target sites. LÄS MER
3. Union-Fertility Nexus and Fertility Variation in Sub-Saharan Africa : The Role of Marital Dissolution and Repartnering
Sammanfattning : The role of marital dissolution and repartnering in shaping fertility patterns in sub-Saharan Africa (SSA) has been largely overlooked, even though marital dissolution and repartnering are fundamental features of marriage dynamics in this region. This dissertation addresses this gap by using existing statistical and demographic techniques and developing new demographic methods to (i) examine the relationship between union dissolution and fertility at the micro level (Study I); (ii) assess the dynamics of union dissolution, including the levels of all-cause first union dissolution, the timing of first union dissolution, and the reproductive years spent outside of marriage due to union dissolution (Studies II & III); and (iii) analyze the influence of marital dissolution and repartnering on macro fertility patterns in SSA (Study IV). LÄS MER
4. Advanced Methods for Evaluation of the Performance of Complex Drug Delivery System
Sammanfattning : Low oral bioavailability of drugs originating from poor aqueous solubility is a common issue in drug development. Various enabling formulations have been presented to circumvent this limitation, many making use of supersaturation. In these, the drug is delivered to the gastro-intestinal lumen in a high energy state e.g. LÄS MER
5. The Challenges of Analyzing the Molecular Properties of Starch
Sammanfattning : Both the nutritional and functional properties of starch are directly influenced by the molecular structure of its polymers: amylose and amylopectin. It is therefore important to have reproducible methods for quantifying the molecular size. LÄS MER