Sökning: "Disease modeling"

Visar resultat 21 - 25 av 194 avhandlingar innehållade orden Disease modeling.

1. 21. Volterra Modeling and Estimation of the Human Smooth Pursuit

   Författare :Viktor Bro; Alexander Medvedev; Geoff Chase; Uppsala universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Volterra models; Volterra-Laguerre models; Nonlinear modeling; Smooth pursuit; Eye tracking; Elektroteknik med inriktning mot reglerteknik; Electrical Engineering with specialization in Automatic Control;

   Sammanfattning : This thesis treats the mathematical modeling of the human smooth pursuit system using Volterra-Laguerre models. The smooth pursuit system allows for tracking of moving objects. Since it is a complex system including the muscles of the eye, nerves and certain parts of the brain, the system may be impaired if some part is compromised. LÄS MER

3. 22. Population Pharmacodynamic Modeling and Methods for D2-receptor Antagonists

   Författare :Klas Petersson; Lena Friberg; Mats Karlsson; An Vermeulen; Robert Bies; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; population modeling; schizophrenia; D2-antagonists; pharmacodynamics; drug development;

   Sammanfattning : Early predictions of a potential drug candidate’s time-course of effect and side-effects, based on models describing drug concentrations, drug effects and disease progression, would be valuable to make drug development more efficient. Pharmacodynamic modeling can incorporate and propagate prior knowledge and be used for simulations of different scenarios. LÄS MER

4. 23. Design and analysis with observational data : Protocols and modeling with the aim of causal inference

   Författare :Paulina Jonéus; Mattias Nordin; Per Johansson; Jenny Häggström; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; observational studies; protocols guidelines; epidemiology; public health; prostate disease; Statistics; Statistik;

   Sammanfattning : This thesis consists of six papers that study the design and analysis with observational data.There is a growing interest in using real-world evidence (RWE) for regulatory purposes. The belief is that observational data can make drug developmentmore efficient and speed up patient access to new drugs. LÄS MER

5. 24. Cholinergic and dopaminergic aspects of dementia in Parkinson's disease: postmortem neuropathological findings and modeling of cognitive dysfunction in rodents

   Författare :Helene Hall; Brain Repair and Imaging in Neural Systems (BRAINS); []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alpha-synuclein; animal model; choline acetyltransferase; cholinergic neurons; cognition; dementia; dopaminergic neurons; Lewy bodies; Parkinson s disease; magnetic resonance spectroscopy;

   Sammanfattning : Motor symptoms are currently considered the first clinical hallmark of Parkinson’s disease (PD). They develop as a result of dopamine loss in the striatum, subsequent to the progressive neurodegeneration of dopamin- ergic neurons in the substantia nigra. LÄS MER

7. 25. The Complex Genetics behind Neurodegeneration and Susceptibility to Parkinson’s disease

   Författare :Michael Jewett; Translationell Neurogenetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s Disease; α-synuclein; Dopaminergic Neurons; Susceptibility; GSTA4; Vra1; rAAV; 6-OHDA; En1; Linkage analysis; Congenic strains; Axonal swellings; QTL; Risk factors; Neuroprotection; Astrocytes;

   Sammanfattning : Parkinson’s disease (PD) is the second most common neurodegenerative disorder and affects over 1% of people above the age of 65. This progressive and debilitating disease is usually thought of as a motor disease, with symptoms such as muscle rigidity, slowness of movement, and tremor at rest. LÄS MER