Sökning: "Dioxin Ah Receptor"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Dioxin Ah Receptor.

  1. 1. Bioassay analysis of dioxin-like compounds : response interactions and environmental transformation of Ah receptor agonists

    Författare :Helena Olsman; Magnus Engwall; John P. Giesy; Örebro universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; bioassay; dioxin-like; Ah receptor; Biology; Biologi; Biology; Biologi;

    Sammanfattning : Dioxin-like compounds mediate their toxicity by binding to the aryl hydrocarbon receptor (AhR) and through this receptor a cascade of biochemical and toxic events are triggered. Mechanism-specific dioxin bioassays utilise the AhR coupled induction of endogenous CYP1A proteins or reporter gene systems for detection of dioxin-like compounds and other AhR ligands. LÄS MER

  2. 2. Functional role of a constitutively active dioxin/Ah receptor in a transgenic mouse model

    Författare :Patrik Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Dioxin Ah receptor; TCDD; dioxin; stomach tumor; osteopontin; peritoneal B1 B cells; transcription factor; gene expression;

    Sammanfattning : The dioxin/ Aryl hydrocarbon receptor is a ligand-activated transcription factor that mediates most (if not all) of the toxic effects of the group of highly potent environmental pollutants collectively called dioxins and PCBs, including the highly toxic compound 2,3,7,8tetrachlorodibenzo-p-dioxin (TCDD). The toxic effects include immune suppression, endocrine disruption, impaired reproduction and carcinogenesis. LÄS MER

  3. 3. Ah receptor mediated toxicity : Studies in vitro and in a Transgenic Mouse Model

    Författare :Sara Brunnberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Dioxin Ah Receptor; Arnt; TCDD; gene expression; reproductive tract; bone; heart;

    Sammanfattning : The polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls are ubiquitously present in the environment. Humans are exposed mainly through diet to continuous low levels which on average are in close proximity to those considered tolerable. The foetus and newborn infant are considered as a particular risk group. LÄS MER

  4. 4. Constitutive and TCDD-induced expression of Ah receptor responsive genes with special focus on the brain and pituitary

    Författare :Ping Huang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : The 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) and related substances are ubiquitous environmental pollutants causing a number of pathological alterations, the most severe being progressive anorexia and body weight loss. The effects on body weight homeostasis suggest a possible involvement of the nervous system and neuroendocrine areas including the pituitary gland. LÄS MER

  5. 5. Formation and metabolism of the tryptophan-derived 6-formylindolo[3,2-b]carbazole - a light-induced Ah-receptor ligand

    Författare :Linda Bergander; Ulf Rannug; Agneta Rannug; Stockholms universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi;

    Sammanfattning : The aryl hydrocarbon receptor (AhR) is a ligand dependent transcription factor ubiquitously expressed in mammalian cells. It is a genetically ancient protein mostly known for binding the extremely toxic contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). LÄS MER