Sökning: "Dihydroorotate dehydrogenase"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Dihydroorotate dehydrogenase.

  1. 1. Inhibitors of Human and Malaria Parasite Dihydroorotate Dehydrogenase

    Författare :Ingela Fritzson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DHODH; Synthesis; Inhibitors.; Dihydroorotate dehydrogenase;

    Sammanfattning : In the first part of the PhD work, small chemical entities (fragments) found to inhibit human dihydroorotate dehydrogenase (DHODH), were chemically optimized. As part of an ample program at Active Biotech to find new drugs against autoimmune diseases, expanded fragments were repeatedly designed, synthesized and evaluated in a human DHODH assay. LÄS MER

  3. 2. Reconstitution of Membrane-Bound Enzymes for Neutron Scattering Studies: A Case Study of Human Dihydroorotate Dehydrogenase

    Författare :Manuel Orozco; Molekylär cellbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; membrane proteins; dihydroorotate dehydrogenase; pyrimidine metabolism; neutron scattering; ubiquinone; QCM-D;

    Sammanfattning : Membrane proteins are challenging to study due the necessity to maintain a lipid-like environment to preserve their structure and function. Particularly difficult to study are membrane-bound enzymes that interact with lipophilic substrates. LÄS MER

  4. 3. Dihydroorotate dehydrogenase : new insights into an old target

    Författare :Gergana Popova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Purine and pyrimidine nucleotides are important for both biosynthetic and regulatory pathways in cells. As constituents of the DNA and RNA molecules, the requirements for nucleotides in actively dividing cells are increased. LÄS MER

  5. 4. Advanced computations and mass-spectrometric techniques to unravel the dynamics and interactions of proteins

    Författare :Joana Costeira-Paulo; Erik Marklund; Lars Konermann; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molecular dynamics; mass spectrometry; dihydroorotate dehydrogenase; alpha-synuclein; protein structure; ion mobility; electrospray ionisation; collision cross section; lipids; gas-phase hydrogen deuterium exchange; collision induced unfolding; Biokemi; Biochemistry;

    Sammanfattning : Proteins are an important class of biomolecules, involved in the metabolism, regulation, structure and transport in cells. Unfortunately, many diseases are caused by protein dysfunction. When proteins perform their normal function, they may interact with each other or change their conformation. LÄS MER

  7. 5. Investigating ALK inhibitors alone or in combination as therapeutic options for ALK-positive neuroblastoma

    Författare :Muhammad Wasi Alam; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Oncology; Anaplastic lymphoma kinase ALK ; Dihydroorotate Dehydrogenase DHODH ;

    Sammanfattning : Neuroblastoma (NBL) is the third most common pediatric cancer after leukemia and cranial tumours and accounts for around 15% of death in pediatric malignancy. NBL develops due to the poorly differentiated progenitor cells of the sympathetic nervous system. LÄS MER