Sökning: "Dihydroorotate Dehydrogenase DHODH"

Hittade 5 avhandlingar innehållade orden Dihydroorotate Dehydrogenase DHODH.

  1. 1. Inhibitors of Human and Malaria Parasite Dihydroorotate Dehydrogenase

    Författare :Ingela Fritzson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DHODH; Synthesis; Inhibitors.; Dihydroorotate dehydrogenase;

    Sammanfattning : In the first part of the PhD work, small chemical entities (fragments) found to inhibit human dihydroorotate dehydrogenase (DHODH), were chemically optimized. As part of an ample program at Active Biotech to find new drugs against autoimmune diseases, expanded fragments were repeatedly designed, synthesized and evaluated in a human DHODH assay. LÄS MER

  3. 2. Dihydroorotate dehydrogenase : new insights into an old target

    Författare :Gergana Popova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Purine and pyrimidine nucleotides are important for both biosynthetic and regulatory pathways in cells. As constituents of the DNA and RNA molecules, the requirements for nucleotides in actively dividing cells are increased. LÄS MER

  4. 3. Investigating ALK inhibitors alone or in combination as therapeutic options for ALK-positive neuroblastoma

    Författare :Muhammad Wasi Alam; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Oncology; Anaplastic lymphoma kinase ALK ; Dihydroorotate Dehydrogenase DHODH ;

    Sammanfattning : Neuroblastoma (NBL) is the third most common pediatric cancer after leukemia and cranial tumours and accounts for around 15% of death in pediatric malignancy. NBL develops due to the poorly differentiated progenitor cells of the sympathetic nervous system. LÄS MER

  5. 4. Advanced computations and mass-spectrometric techniques to unravel the dynamics and interactions of proteins

    Författare :Joana Costeira-Paulo; Erik Marklund; Lars Konermann; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molecular dynamics; mass spectrometry; dihydroorotate dehydrogenase; alpha-synuclein; protein structure; ion mobility; electrospray ionisation; collision cross section; lipids; gas-phase hydrogen deuterium exchange; collision induced unfolding; Biokemi; Biochemistry;

    Sammanfattning : Proteins are an important class of biomolecules, involved in the metabolism, regulation, structure and transport in cells. Unfortunately, many diseases are caused by protein dysfunction. When proteins perform their normal function, they may interact with each other or change their conformation. LÄS MER

  7. 5. Retinal tumorigenesis and neurodegeneration : strategies to promote tumor cell death and support retinal cell survival to preserve vision

    Författare :Tanzina Mollick; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Our vision is central to our quality of life enabling us to interact with our environment and lead productive lives. The ability to see begins in the retina, one of the paramount features of the eye, as it takes on the task of converting light signals to nerve impulses that are relayed to the visual centers of the brain. LÄS MER