Sökning: "Digital tablets"

Visar resultat 16 - 20 av 31 avhandlingar innehållade orden Digital tablets.

1. 16. Flow and Compression of Granulated Powders : The Accuracy of Discrete Element Simulations and Assessment of Tablet Microstructure

   Författare :Ann-Sofie Persson; Göran Frenning; Göran Alderborn; Marie Wahlgren; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Discrete Element Method; Granule; Flow; Angle of Repose; Discharge Rate; Shear; Rolling friction; Compression; Elastic deformation; Microstructure; Degree of compression; Tensile strength; Galenisk farmaci; Pharmaceutics;

   Sammanfattning : Simulations are powerful and important tools for gaining insight into powder processes. Ultimately, simulations have the potential to replace experiments. Thus, accurate models and insight into the essential factors for descriptions of powder behaviour are required. LÄS MER

3. 17. Separation of Pharmaceuticals by Capillary Electrophoresis using Partial Filling and Multiple-injections

   Författare :Henrik Lodén; Curt Pettersson; Torbjörn Arvidsson; Ahmad Amini; Morgan Stefansson; Uppsala universitet; []
   Nyckelord :Capillary Coating; Chiral Separation; Enantiomers; Mass-spectrometric Detection; Method Validation; Multiple-injection Capillary Zone Electrophoresis; Non-aqueous Capillary Electrophoresis; Organic Solvents; Pharmaceutical Analysis; Quantitative Analysis;

   Sammanfattning : Different multiple-injection methodologies and the partial filling technique (PFT) have been utilized for separation of pharmaceuticals by capillary elec-trophoresis. In multiple-injection capillary zone electrophoresis (MICZE), the samples and all standards, used for construction of the calibration curve, are analyzed within a single run. LÄS MER

4. 18. Identification and Variation of some Functionality Related Characteristics of Pharmaceutically Relevant Solid Materials and their Effect on Product Performance

   Författare :Frauke Fichtner; Göran Alderborn; Åke Rasmuson; Peter Kleinebudde; Uppsala universitet; []
   Nyckelord :Pharmaceutics; Particle size distribution; Degree of agglomeration; Amorphous lactose; Matrix agglomerates; Drug release; Compactability; Tablet tensile strength; Particle fracture strength; Surfactant; Compression; Galenisk farmaci;

   Sammanfattning : The aim of this thesis was to identify some functionality related characteristics of pharmaceutically relevant solid materials and to study the effect of their variation on processing behaviour and product performance. For this purpose, particles with different characteristics were prepared under a variety of conditions by crystal agglomeration, wet granulation and spray drying. LÄS MER

5. 19. Compression Mechanics of Powders and Granular Materials Probed by Force Distributions and a Micromechanically Based Compaction Equation

   Författare :Foad Mahmoodi; Göran Frenning; Bruno Hancock; Uppsala universitet; []
   Nyckelord :compression; powder; mechanical properties; pellet; tablet; compaction equation; force distribution;

   Sammanfattning : The internal dynamics of powder systems under compression are as of yet not fully understood, and thus there is a necessity for approaches that can help in further clarifying and enhancing the level of understanding on this subject. To this end, the internal dynamics of powder systems under compression were probed by means of force distributions and a novel compaction equation. LÄS MER

7. 20. Longitudinal Models for Quantifying Disease and Therapeutic Response in Multiple Sclerosis

   Författare :Ana M. Novakovic; Mats O. Karlsson; Etienne Pigeolet; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed-effects models; pharmacometrics; NONMEM; multiple sclerosis; cladribine; EDSS; item response theory; relapse rate; absolute lymphocyte count; total volume T2 lesions; burden of disease; power; sample size; Pharmaceutical Science; Farmaceutisk vetenskap;

   Sammanfattning : Treatment of patients with multiple sclerosis (MS) and development of new therapies have been challenging due to the disease complexity and slow progression, and the limited sensitivity of available clinical outcomes. Modeling and simulation has become an increasingly important component in drug development and in post-marketing optimization of use of medication. LÄS MER