Sökning: "Diez"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet Diez.

  1. 1. Neuropeptide expression in mouse disease models

    Författare :Margarita Diez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alzheimers disease; autoradiographic ligand binding; CCK; degeneration; dynorphin; enkephalin; galanin; immunohistochemistry; in situ hybridization; lesion; magnetic resonance imaging; megencephaly; NPY; prion infection; substance P.;

    Sammanfattning : The role of neuropeptides and the significance of peptidergic mechanisms in neurodegenerative diseases are still relatively unexplored. In the periphery, nerve injury results in dramatic changes in the expression of neuropeptides (and other molecules). LÄS MER

  3. 2. Mechanisms Underlying Intensive Care Unit Muscle Wasting : Intervention Strategies in an Experimental Animal Model and in Intensive Care Unit Patients

    Författare :Monica Llano-Diez; Lars Larsson; Marco Sandri; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute quadriplegic myopathy; intensive care unit; myosin; regulation of contraction; muscle atrophy; mechanical loading; mobilization; Clinical Neurophysiology; Klinisk neurofysiologi;

    Sammanfattning : Critically ill patients admitted to the intensive care unit (ICU) commonly develop severe muscle wasting and weakness and consequently impaired muscle function. This not only delays respirator weaning and ICU discharge, but has deleterious effects on morbidity, mortality, financial costs, and quality of life of survivors. LÄS MER

  4. 3. Sampling from molecular unnormalized distributions with Deep Generative Models

    Författare :Juan Viguera Diez; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; machine learning; Cheminformatics; conformational sampling; generative models; drug discovery; Boltzmann generators;

    Sammanfattning : This thesis investigates how Deep Generative Models (DGMs) can address important drug discovery problems involving sampling from unnormalized distributions. It consists of two papers focusing on this challenge’s aspects: molecular design and conformational sampling. LÄS MER

  5. 4. Palaeogenomic reconstruction of woolly mammoth evolutionary history and extinction dynamics

    Författare :Marianne Dehasque; Love Dalén; David Díez-del-Molino; Rike Stelkens; Rebecca N. Johnson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; woolly mammoth; Mammuthus primigenius; extinction; Wrangel Island; ancient DNA; palaeogenomics; radiocarbon dating; structural variants; genome erosion; population structure; Systematic Zoology; zoologisk systematik och evolutionsforskning;

    Sammanfattning : Biodiversity is declining globally. Yet, the biological and genetic processes associated with these declines on a longer timescale are still poorly understood. Ancient DNA is a powerful tool to study evolution in real-time. Despite advances in the field, there is further need for refinement of laboratory and computational techniques. LÄS MER

  7. 5. Genetic variability and nitrogenase activity of cyanobacterial communities associated with tropical seagrass meadows (western Indian Ocean)

    Författare :Mariam Hamisi; Birgitta Bergman; Thomas Lyimo; Beatriz Díez; Lucas Stal; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cyanobacteria; nitrogenase activity; diazotrophs; seagrass; western Indian ocean; Plant physiology; Växtfysiologi; Plant Physiology; växtfysiologi;

    Sammanfattning : Tropical seagrass ecosystems are highly productive and important for sustaining marine life and associated coastal societies. In this study, the diversity and role of nitrogen-fixing cyanobacteria associated with five common seagrass genera in coastal regions of the western Indian Ocean (WIO; Tanzania) were examined, as well as the impact of anthropogenic activities. LÄS MER