Sökning: "Desmosomes"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet Desmosomes.

  1. 1. Cell Contacts and Airway Epithelial Damage in Asthma

    Författare :Shahida Shahana; Godfried Roomans; Rolf Odselius; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anatomy; Desmosomes; tight junctions; major basic protein; eosinophil; cytokines; epithelial damage.; Anatomi; Anatomy; Anatomi;

    Sammanfattning : Airway epithelial damage is commonly found in asthma patients. Epithelial damage was investigated with special reference to contacts between epithelial cells.Eosinophils, common in allergic asthma, secrete cationic proteins, particularly major basic protein (MBP). LÄS MER

  3. 2. Effects of Th-1 and Th-2 Cytokines and Reactive Oxygen Species on Normal Human Bronchial Epithelial Cells

    Författare :Caroline Kampf; Benjamin Gaston; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; ytokines; desmosomes; focal adhesions; free radicals; hypochlorous acid; nitric oxide; normal human bronchial epithelial cells; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Epithelial damage and shedding of the epithelium are common observations in many airway diseases such as asthma, Sjögren’s syndrome, chronic obstructive pulmonary disease and cystic fibrosis. The ability of the cells to attach to each other and/or to the matrix seems to be altered. LÄS MER

  4. 3. Ultrastructural Studies of the Airway Epithelium in Airway Diseases

    Författare :Eyman Shebani; Godfried M. Roomans; Marie Johannesson; Anil Mehta; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Morphology; asthma; cilia; corticosteroids; cytokines; desmosomes; Gaucher’s disease; montelukast; primary ciliary dyskinesia; transmission electron microscopy; Morfologi; Morphology; cell biology; pathology; Morfologi; cellbiologi; patologi;

    Sammanfattning : Ultrastructural studies of airway epithelium in airway disease are important for diagnosis and understanding the underlying pathology which helps clinicians to improve the patients' treatment.Airway biopsies from a 5-month old boy with respiratory problems and gastro-oesophageal reflux were studied by transmission electron microscopy (TEM). LÄS MER

  5. 4. Differential expression pattern of CEACAM1 isoforms in polarized epithelial cells : it's regulation and some functional consequences

    Författare :Ulla Sundberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CEACAM1; adhesion; lateral localization; adherens junctions; desmosomes; primary cilia;

    Sammanfattning : The cell adhesion molecule CEACAM1 is expressed in epithelia, small vessel endothelia and leukocytes as two major, co-expressed isoforms, CEACAM1-L and CEACAM1-S, which differ in their cytoplasmic domains. CEACAM1 has been found both in cell-cell contact areas and on apical surfaces of polarized epithelial cells. LÄS MER

  7. 5. Genetic and Molecular Studies of Two Hereditary Skin Disorders

    Författare :Johanna Dahlqvist; Niklas Dahl; Anders Vahlquist; Juha Kere; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Monogenic disorder; autosomal recessive congenital ichthyosis; KLICK syndrome; Ichthyin; POMP; proteasome; epidermal differentiation; Clinical genetics; Klinisk genetik; Clinical Genetics; Klinisk genetik;

    Sammanfattning : Monogenic disorders, i.e., disorders caused by mutations in a single gene, are rare and clinically heterogeneous conditions. Identification of the genetic cause of monogenic traits can bring new insights into molecular pathways and disease mechanisms. LÄS MER