Sökning: "Descriptor Systems"

Visar resultat 6 - 10 av 28 avhandlingar innehållade orden Descriptor Systems.

  1. 6. Ligand-based Methods for Data Management and Modelling

    Författare :Jonathan Alvarsson; Jarl E. S. Wikberg; Ola Spjuth; Claes Andersson; Martin Eklund; John P. Overington; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; QSAR; ligand-based drug discovery; bioclipse; information system; cheminformatics; bioinformatics; Farmaceutisk farmakologi; Pharmaceutical Pharmacology; Bioinformatik; Bioinformatics;

    Sammanfattning : Drug discovery is a complicated and expensive process in the billion dollar range. One way of making the drug development process more efficient is better information handling, modelling and visualisation. The majority of todays drugs are small molecules, which interact with drug targets to cause an effect. LÄS MER

  3. 7. Towards Classification and Functional Description of Enzymes: A case study of feruloyl esterases

    Författare :Gupta Udatha; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; descriptors; enzyme immobilization; catalytic triad; pharmacophore; enzyme promiscuity; functional classification; molecular docking; feruloyl esterases; protein evolution; structure-function relationship;

    Sammanfattning : The prediction of enzyme functionality from sequence or structure data remains a challenging task that can be best addressed by studying the structure-function relationships determined from previously available information. This thesis work was focused on developing a reliable classification and functional description for the feruloyl esterase (FAE) enzyme family, whose members’ possess both structural and catalytic promiscuity. LÄS MER

  4. 8. Efficient Map Matching and Discovery of Frequent and Dominant Movement Patterns in GPS Trajectory Data

    Författare :Can Yang; Yifang Ban; Gyözö Gidofalvi; Xiaoliang Ma; Mirco Nanni; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; map matching; contiguous sequential pattern mining; contiguous sequential pattern comparison; movement pattern detection; Kartmatchning; sammanhängande sekventiellt mönster utvinning; sammanhängande sekventiellt mönster jämförelse; rörelsemönster detektering; Geoinformatics; Geoinformatik;

    Sammanfattning : The wide deployment of Global Positioning System (GPS) sensors for movement data collection has enabled a wide range of applications in transportation and urban planning. Frequent and dominant movement patterns embedded in GPS trajectory data provide valuable knowledge including the spatial and temporal distribution of frequent routes selected by the tracked objects and the regular movement behavior in certain regions. LÄS MER

  5. 9. On Observation of and Interaction in Open Distributed Systems

    Författare :Jens-Olof Lindh; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Coherence; interaction; temporal interval; relativity; uncertainty;

    Sammanfattning : The thesis presents the results of research in computer science, as applied within a series of industrial projects. All of these projects have been part of an iterative and adaptive development process, from which we can draw conclusions in three different aspects. LÄS MER

  7. 10. Diagnosability analysis and FDI system design for uncertain systems

    Författare :Daniel Eriksson; Erik Frisk; Mattias Krysander; Alexander Medvedev; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Our society depends on advanced and complex technical systems and machines, for example, cars for transportation, industrial robots in production lines, satellites for communication, and power plants for energy production. Consequences of a fault in such a system can be severe and result in human casualties, environmentally harmful emissions, high repair costs, or economical losses caused by unexpected stops in production lines. LÄS MER